干旱区生态环境知识资源中心(Arid): Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis

Arid

DOI	10.3390/microorganisms7020031
	Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis
	Lauer, Antje 1; Baal, Joe Darryl 1; Mendes, Susan D.1; Casimiro, Kayla Nicole 1; Passaglia, Alyce Kayes 1; Valenzuela, Alex Humberto 1; Guibert, Gerry 2
通讯作者	Lauer, Antje
来源期刊	MICROORGANISMS
EISSN	2076-2607
出版年	2019
卷号	7 期号:2
英文摘要	The incidence of coccidioidomycosis, also known as Valley Fever, is increasing in the Southwestern United States and Mexico. Despite considerable efforts, a vaccine to protect humans from this disease is not forthcoming. The aim of this project was to isolate and phylogenetically compare bacterial species that could serve as biocontrol candidates to suppress the growth of Coccidioides immitis, the causative agent of coccidioidomycosis, in eroded soils or in areas close to human settlements that are being developed. Soil erosion in Coccidioides endemic areas is leading to substantial emissions of fugitive dust that can contain arthroconidia of the pathogen and thus it is becoming a health hazard. Natural microbial antagonists to C. immitis, that are adapted to arid desert soils could be used for biocontrol attempts to suppress the growth of the pathogen in situ to reduce the risk for humans and animals of contracting coccidioidomycosis. Bacteria were isolated from soil samples obtained near Bakersfield, California. Subsequently, pairwise challenge assays with bacterial pure cultures were initially performed against Uncinocarpus reesii, a non-pathogenic relative of C. immitis on media plates. Bacterial isolates that exhibited strongly antifungal properties were then re-challenged against C. immitis. Strongly anti-C. immitis bacterial isolates related to Bacillus subtilis and Streptomyces spp. were isolated, and their antifungal spectrum was investigated using a selection of environmental fungi.
英文关键词	Coccidioides immitis Valley Fever biocontrol microbial antagonists challenge assays arid soils
类型	Article
语种	英语
国家	USA
开放获取类型	Green Published, gold, Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000460169900015
WOS关键词	16S RIBOSOMAL-RNA ; CUTANEOUS BACTERIA ; UNITED-STATES ; SOIL ; BIODIVERSITY ; RHIZOSPHERE ; CALIFORNIA ; ECOLOGY ; GENES ; SUPPRESSION
WOS类目	Microbiology
WOS研究方向	Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217609
作者单位	1.Calif State Univ Bakersfield, Dept Biol, 9001 Stockdale Highway, Bakersfield, CA 93311 USA; 2.Monterey Cty Hlth Dept, 1270 Natividad, Salinas, CA 93906 USA
推荐引用方式 GB/T 7714	Lauer, Antje,Baal, Joe Darryl,Mendes, Susan D.,et al. Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis[J],2019,7(2).
APA	Lauer, Antje.,Baal, Joe Darryl.,Mendes, Susan D..,Casimiro, Kayla Nicole.,Passaglia, Alyce Kayes.,...&Guibert, Gerry.(2019).Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis.MICROORGANISMS,7(2).
MLA	Lauer, Antje,et al."Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis".MICROORGANISMS 7.2(2019).