干旱区生态环境知识资源中心(Arid): Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater

Arid

DOI	10.1016/j.microc.2019.04.047
	Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater
	Krakko, Daniel ; Licul-Kucera, Viktoria ; Zaray, Gyula ; Mihucz, Victor G.1
通讯作者	Mihucz, Victor G.
来源期刊	MICROCHEMICAL JOURNAL
ISSN	0026-265X
EISSN	1095-9149
出版年	2019
卷号	148 页码:108-119
英文摘要	A fit-to-purpose ultra-high performance liquid chromatographic high resolution mass spectrometric method was developed for the ultra-trace analysis of 10 active pharmaceutical ingredients in one chromatographic run as follows: atorvastatin, carbamazepine (CARB), ciprofloxacin (CIPR), clarithromycin (CZAR), diclofenac (DICL), metoprolol (METO), naproxen (NAPA), sitagliptin (SITA), sulfamethoxazole (SULF) and tetracycline. By applying Oasis HLB solid phase extraction cartridges, a 1250-fold enrichment was achieved. For quantitative determination, intemal standard calibration was applied. Lower limits of quantification for the analytes were <= 0.025 mu g/L. Good linearity was found between 0.01 and 5 mu g/L in most cases. Generally, overall recovery for drinking, river and treated wastewater samples spiked with the target analytes at one concentration level comparable with the blank values and another one by one order of magnitude higher was between 80 and 120%. The relative standard deviation values were <= 16%. The proposed method has been applied for the aforementioned water matrices sampled monthly between January and March 2019. Concentration of GARB in drinking water per se was about 0.025 mu g/L, confirming the low removal rates during river bank filtration applied for drinking water production. Seven compounds were present in the river water in <= 50 ng/L. Eight compounds were detected at least once from the treated wastewater samples including CARB, DICL, NAPR and SITA in > 1 mu g/L. Concentration of CARB, DICL, METO, SITA used for chronic affections was almost constant during the monitored time period. To the contrary, concentration of CIPR, CLAR, SULF used for acute infections registered peak values in the same samples taken in winter.
英文关键词	Carbamazepine Danube River High resolution mass spectrometry Pharmaceutical residues Surface water Watch List
类型	Article
语种	英语
国家	Hungary
收录类别	SCI-E
WOS记录号	WOS:000474492600015
WOS关键词	PERSONAL CARE PRODUCTS ; ENVIRONMENTAL RISK-ASSESSMENT ; SUSPENDED PARTICULATE MATTER ; TREATMENT-PLANTS ; SURFACE-WATER ; TETRACYCLINE ANTIBIOTICS ; SEASONAL OCCURRENCE ; EMERGING CONCERN ; DANUBE RIVER ; DRUGS
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217607
作者单位	1.Eotvos Lorand Univ, Inst Chem, Lab Environm Chem & Bioanalyt, Pazmany Peter Setany 1-A, H-1117 Budapest, Hungary; 2.Eotvos Lorand Univ, Inst Chem, Cooperat Res Ctr Environm Sci, Pazmany Peter Setany 1-A, H-1117 Budapest, Hungary
推荐引用方式 GB/T 7714	Krakko, Daniel,Licul-Kucera, Viktoria,Zaray, Gyula,et al. Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater[J],2019,148:108-119.
APA	Krakko, Daniel,Licul-Kucera, Viktoria,Zaray, Gyula,&Mihucz, Victor G..(2019).Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater.MICROCHEMICAL JOURNAL,148,108-119.
MLA	Krakko, Daniel,et al."Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater".MICROCHEMICAL JOURNAL 148(2019):108-119.