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DOI | 10.1002/kjm2.12022 |
In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study | |
Liang, Lin-Lin1; Su, Zheng-Bing2 | |
通讯作者 | Su, Zheng-Bing |
来源期刊 | KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
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ISSN | 1607-551X |
EISSN | 2410-8650 |
出版年 | 2019 |
卷号 | 35期号:3页码:175-182 |
英文摘要 | Bone tendon junction injury is hard to cure because of its special anatomical structure, and the treatment applied for bone-tendon junction injury cannot result in the perfect vascular regeneration and restoration of the fibrocartilage zone. In this article, we aim to explore the effect of caveolin-1 as a slow-release material on bone-tendon junction healing. Seventy-two New Zealand rabbits were randomly selected and assigned into the experimental, sham-operated and control groups (n = 24). Caveolin-1 microspheres and microcapsule were developed as drug delivery system. At the 4th, 8th, arid 12th weeks after surgery, quadriceps muscle patella-patellar tendon (QMPPT) was obtained from each rabbit to observe the tendon-to-bone tunnel healing, and X-ray examination, histological examination and biomechanical testing were applied for evaluating new bone formation. As the X-ray showed, caveolin-1 increased the new bone area at each time point. At the 4th and 8th weeks after surgery, the rabbit treated with caveolin-1 slow release material showed repair of fibrocartilage. According to the biomechanical results, the cross-sectional area, breaking load and ultimate tensile strength were increased along with time. At the same time point, caveolin-1 increased the ultimate tensile strength. Our study demonstrates that caveolin-1 as a slow-release material could accelerate bone-tendon junction healing by promoting the formation of the transition zone. |
英文关键词 | bone biomechanical properties bone-tendon junction healing caveolin-1 slow-release material |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
开放获取类型 | gold |
收录类别 | SCI-E |
WOS记录号 | WOS:000461858700007 |
WOS关键词 | ANIMAL-MODEL ; EXPRESSION ; HEAD ; REGENERATION ; MICE |
WOS类目 | Medicine, Research & Experimental |
WOS研究方向 | Research & Experimental Medicine |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/217444 |
作者单位 | 1.Second Peoples Hosp Jiulongpo Dist, Dept Clin Lab, Chongqing, Peoples R China; 2.Army Med Univ, Dept Orthoped, Affiliated Hosp 2, 83 Xinqiao Main St, Chongqing 400037, Peoples R China |
推荐引用方式 GB/T 7714 | Liang, Lin-Lin,Su, Zheng-Bing. In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study[J],2019,35(3):175-182. |
APA | Liang, Lin-Lin,&Su, Zheng-Bing.(2019).In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study.KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,35(3),175-182. |
MLA | Liang, Lin-Lin,et al."In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study".KAOHSIUNG JOURNAL OF MEDICAL SCIENCES 35.3(2019):175-182. |
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