干旱区生态环境知识资源中心(Arid): In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study

Arid

DOI	10.1002/kjm2.12022
	In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study
	Liang, Lin-Lin 1; Su, Zheng-Bing 2
通讯作者	Su, Zheng-Bing
来源期刊	KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
ISSN	1607-551X
EISSN	2410-8650
出版年	2019
卷号	35 期号:3 页码:175-182
英文摘要	Bone tendon junction injury is hard to cure because of its special anatomical structure, and the treatment applied for bone-tendon junction injury cannot result in the perfect vascular regeneration and restoration of the fibrocartilage zone. In this article, we aim to explore the effect of caveolin-1 as a slow-release material on bone-tendon junction healing. Seventy-two New Zealand rabbits were randomly selected and assigned into the experimental, sham-operated and control groups (n = 24). Caveolin-1 microspheres and microcapsule were developed as drug delivery system. At the 4th, 8th, arid 12th weeks after surgery, quadriceps muscle patella-patellar tendon (QMPPT) was obtained from each rabbit to observe the tendon-to-bone tunnel healing, and X-ray examination, histological examination and biomechanical testing were applied for evaluating new bone formation. As the X-ray showed, caveolin-1 increased the new bone area at each time point. At the 4th and 8th weeks after surgery, the rabbit treated with caveolin-1 slow release material showed repair of fibrocartilage. According to the biomechanical results, the cross-sectional area, breaking load and ultimate tensile strength were increased along with time. At the same time point, caveolin-1 increased the ultimate tensile strength. Our study demonstrates that caveolin-1 as a slow-release material could accelerate bone-tendon junction healing by promoting the formation of the transition zone.
英文关键词	bone biomechanical properties bone-tendon junction healing caveolin-1 slow-release material
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000461858700007
WOS关键词	ANIMAL-MODEL ; EXPRESSION ; HEAD ; REGENERATION ; MICE
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217444
作者单位	1.Second Peoples Hosp Jiulongpo Dist, Dept Clin Lab, Chongqing, Peoples R China; 2.Army Med Univ, Dept Orthoped, Affiliated Hosp 2, 83 Xinqiao Main St, Chongqing 400037, Peoples R China
推荐引用方式 GB/T 7714	Liang, Lin-Lin,Su, Zheng-Bing. In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study[J],2019,35(3):175-182.
APA	Liang, Lin-Lin,&Su, Zheng-Bing.(2019).In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study.KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,35(3),175-182.
MLA	Liang, Lin-Lin,et al."In vitro effect of caveolin-1 as a slow-release material on bone-tendon junction healing: A comparative study".KAOHSIUNG JOURNAL OF MEDICAL SCIENCES 35.3(2019):175-182.