干旱区生态环境知识资源中心(Arid): Inhibitory potential of prickly pears and their isolated bioactives against digestive enzymes linked to type 2 diabetes and inflammatory response

Arid

DOI	10.1002/jsfa.9917
	Inhibitory potential of prickly pears and their isolated bioactives against digestive enzymes linked to type 2 diabetes and inflammatory response
	Gomez-Maqueo, Andrea 1,2; Garcia-Cayuela, Tomas 3; Fernandez-Lopez, Rebeca 1; Welti-Chanes, Jorge 2; Pilar Cano, M.1,2
通讯作者	Pilar Cano, M.
来源期刊	JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
ISSN	0022-5142
EISSN	1097-0010
出版年	2019
卷号	99 期号:14 页码:6380-6391
英文摘要	BACKGROUND Prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. They are sources of betalains and phenolic compounds, which have been reported to contribute to human health. The study of the biological activity of different varieties and of their isolated bioactive constitutes is fundamental in the design of functional foods. In this context, our objective is the assessment of the ability of Spanish and Mexican prickly-pear cultivars to inhibit enzymes related to type 2 diabetes and the inflammatory response, and the contribution of their bioactive compounds to their nutra-pharmaceutical potential. RESULTS Prickly pear peels presented the highest antioxidant activity due to their high isorhamnetin glycoside content. Isorhamnetin glycosides showed significantly higher antioxidant and anti-inflammatory activity than aglycone, particularly isorhamnetin glucosyl-rhamnosyl-pentoside (IG2), which also reported antihyperglycemic activity. Morada, Vigor, and Sanguinos whole fruits exhibited moderate alpha-amylase inhibition and higher alpha-glucosidase inhibition, which is ideal for lowering glucose absorption in hyperglycemia management. Sanguinos peels presented the highest anti-inflammatory activity because of their high indicaxanthin content and isorhamnetin glycoside profile. CONCLUSIONS In the design of prickly pear functional foods, technological processing should prioritize the retention or concentration of these bioactive compounds to preserve (or increase) their natural antioxidant, antihyperglycemic and anti-inflammatory activity. Peels of red and orange varieties should be further evaluated for antioxidant and anti-inflammatory purposes while whole fruits of red and purple varieties could be considered possible candidates for hyperglycemia management. (c) 2019 Society of Chemical Industry
英文关键词	antihyperglycemic activity anti-inflammatory activity antioxidant activity bioactive compounds prickly pears
类型	Article
语种	英语
国家	Spain ; Mexico
收录类别	SCI-E
WOS记录号	WOS:000480437000001
WOS关键词	OPUNTIA-FICUS-INDICA ; ANTIINFLAMMATORY ACTIVITY ; ANTIOXIDANT CAPACITY ; ISORHAMNETIN GLYCOSIDES ; PHENOLIC COMPOSITION ; IN-VITRO ; CLADODES ; FRUITS ; PROFILE
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217384
作者单位	1.CSIC UAM, Inst Invest Ciencias Alimentac CIAL, Dept Biotecnol & Microbiol Alimentos, Nicolas Cabrera 9, Madrid 28049, Spain; 2.Tecnol Monterrey, Ctr Biotecnol FEMSA, Escuela Ingn & Ciencias, Monterrey, Mexico; 3.Tecnol Monterrey, Escuela Ingn & Ciencias, Zapopan, Mexico
推荐引用方式 GB/T 7714	Gomez-Maqueo, Andrea,Garcia-Cayuela, Tomas,Fernandez-Lopez, Rebeca,et al. Inhibitory potential of prickly pears and their isolated bioactives against digestive enzymes linked to type 2 diabetes and inflammatory response[J],2019,99(14):6380-6391.
APA	Gomez-Maqueo, Andrea,Garcia-Cayuela, Tomas,Fernandez-Lopez, Rebeca,Welti-Chanes, Jorge,&Pilar Cano, M..(2019).Inhibitory potential of prickly pears and their isolated bioactives against digestive enzymes linked to type 2 diabetes and inflammatory response.JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,99(14),6380-6391.
MLA	Gomez-Maqueo, Andrea,et al."Inhibitory potential of prickly pears and their isolated bioactives against digestive enzymes linked to type 2 diabetes and inflammatory response".JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 99.14(2019):6380-6391.