干旱区生态环境知识资源中心(Arid): Effectiveness and Safety of Platelet ADP-P2Y 12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis

Arid

DOI	10.1161/JAHA.118.010889
	Effectiveness and Safety of Platelet ADP-P2Y 12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis
	Liu, Zhiyan 1,3; Xiang, Qian 1; Mu, Guangyan 1; Xie, Qiufen 1; Zhou, Shuang 1; Wang, Zining 1; Chen, Shuqing 1; Hu, Kun 1; Gong, Yanjun 2; Jiang, Jie 2; Cui, Yimin 1,3
通讯作者	Cui, Yimin
来源期刊	JOURNAL OF THE AMERICAN HEART ASSOCIATION
EISSN	2047-9980
出版年	2019
卷号	8 期号:7
英文摘要	Background-As reports on the influence of cigarette smoking, an important cardiovascular risk factor, on platelet ADP-P2Y12 receptor inhibitors lack consistency, we aimed to assess the effectiveness and safety of platelet ADP-P2Y12 receptor inhibitors influenced by smoking status. Methods and Results-PubMed, Web of Science, EMBASE, Clinical Trials, and the Cochrane Library were searched from inception until June 2018. Among the 5076 citations retrieved, 22 studies, including 163 011 patients with or without percutaneous coronary intervention, were included for meta-analysis. Compared with nonsmokers within the first year of follow-up, the reductions of stroke and major adverse cardiovascular event rate were 18% (P=0.008) and 26% (P=0.02), respectively. A 20% reduction in stroke (P=0.02) and a 34% reduction in major adverse cardiovascular event (P=0.0001) rates were observed in smoking patients without percutaneous coronary intervention. No significant difference was observed in clinical outcome rates among prasugrel, ticagrelor, and clopidogrel in different smoking status. No significant difference was found in myocardial infarction and bleeding event incidence between current smokers and nonsmokers. Conclusions-We concluded that current smokers had a lower incidence of major adverse cardiovascular events and stroke events than did nonsmokers, particularly in the early period (1 year) and among patients without percutaneous coronary intervention. However, because of the lack of original adjusted data, smoker's paradox still needs to consider the impact of age and other covariates. Thus, a differential risk-benefit evaluation should be considered, according to different smoking status, patient conditions, and therapy time points.
英文关键词	effectiveness meta-analysis platelet aggregation inhibitors safety smoking
类型	Review
语种	英语
国家	Peoples R China
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000484574300011
WOS关键词	PERCUTANEOUS CORONARY INTERVENTION ; ELEVATION MYOCARDIAL-INFARCTION ; DUAL ANTIPLATELET THERAPY ; CURRENT-OASIS 7 ; CIGARETTE-SMOKING ; CLINICAL-OUTCOMES ; JAPANESE PATIENTS ; VS. CLOPIDOGREL ; ARTERY-DISEASE ; EFFICACY
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
来源机构	北京大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217358
作者单位	1.Peking Univ, Hosp 1, Dept Pharm, 6 Dahongluochang St, Beijing 100034, Peoples R China; 2.Peking Univ, Hosp 1, Cardiol, Beijing, Peoples R China; 3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhiyan,Xiang, Qian,Mu, Guangyan,et al. Effectiveness and Safety of Platelet ADP-P2Y 12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis[J]. 北京大学,2019,8(7).
APA	Liu, Zhiyan.,Xiang, Qian.,Mu, Guangyan.,Xie, Qiufen.,Zhou, Shuang.,...&Cui, Yimin.(2019).Effectiveness and Safety of Platelet ADP-P2Y 12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis.JOURNAL OF THE AMERICAN HEART ASSOCIATION,8(7).
MLA	Liu, Zhiyan,et al."Effectiveness and Safety of Platelet ADP-P2Y 12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis".JOURNAL OF THE AMERICAN HEART ASSOCIATION 8.7(2019).