干旱区生态环境知识资源中心(Arid): Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine

Arid

DOI	10.1002/jssc.201801101
	Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine
	Woznica, Marcin; Lulinski, Piotr
通讯作者	Lulinski, Piotr
来源期刊	JOURNAL OF SEPARATION SCIENCE
ISSN	1615-9306
EISSN	1615-9314
出版年	2019
卷号	42 期号:7 页码:1412-1422
英文摘要	The objective of this article was to design the selective molecularly imprinted sorbent dedicated to the solid-phase extraction of S-pramipexole from the complex matrix such as human urine. For that purpose, S-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was used as the template acting as the structural analog of S-pramipexole and five various monomers were employed in the presence of ethylene glycol dimethacrylate to produce molecularly imprinted polymers. The binding capabilities of resulted polymers revealed that the highest imprinting effect was noted for polymer prepared from the itaconic acid. The comprehensive analysis of morphology and the characterization of binding sites showed not only negligible differences in the extension of surfaces of imprinted and nonimprinted polymers but also higher heterogeneity of binding sites in the imprinted material. Comprehensive optimization of the molecularly imprinted solid-phase extraction allowed to select the most appropriate solvents for loading, washing, and elution steps. Subsequent optimization of mass of sorbent and volumes of solvents allowed to achieve satisfactory total recoveries of S-pramipexole from the model multicomponent real sample of human urine that equals to 91.8 +/- 3.2% for imprinted sorbent with comparison to only 37.1 +/- 1.1% for Oasis MCX.
英文关键词	human urine molecularly imprinted polymers pramipexole solid-phase extraction sorbents
类型	Article
语种	英语
国家	Poland
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000466423100012
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; ORGANIC-COMPOUNDS ; DOPAMINE AGONIST ; HUMAN PLASMA ; POLYMER ; DEXPRAMIPEXOLE ; VALIDATION ; SEPARATION ; AREA
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217316
作者单位	Med Univ Warsaw, Fac Pharm, Dept Organ Chem, Banacha 1, PL-02097 Warsaw, Poland
推荐引用方式 GB/T 7714	Woznica, Marcin,Lulinski, Piotr. Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine[J],2019,42(7):1412-1422.
APA	Woznica, Marcin,&Lulinski, Piotr.(2019).Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine.JOURNAL OF SEPARATION SCIENCE,42(7),1412-1422.
MLA	Woznica, Marcin,et al."Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine".JOURNAL OF SEPARATION SCIENCE 42.7(2019):1412-1422.