干旱区生态环境知识资源中心(Arid): Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: Monitoring in Douro River estuary

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DOI	10.1016/j.jpba.2019.03.032
	Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: Monitoring in Douro River estuary
	Coelho, Maria Miguel 1,2; Lado Ribeiro, Ana Rita 3; Sousa, Joao C. G.3; Ribeiro, Claudia 1,4; Fernandes, Carla 2,4; Silva, Adrian M. T.3; Tiritan, Maria Elizabeth 1,2,4
通讯作者	Lado Ribeiro, Ana Rita ; Tiritan, Maria Elizabeth
来源期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
EISSN	1873-264X
出版年	2019
卷号	170 页码:89-101
英文摘要	This work presents the development of an enantioselective method to quantify chiral drugs (CDs) in surface water and its application in the Douro River estuary monitoring. Different classes of CDs were targeted, including 23 compounds, namely beta-blockers, antidepressants, one beta(2)-adrenergic agonist, non-steroidal anti-inflammatory drugs, stimulants, and some illicit drugs as cocaine (COC) and its metabolites, and amphetamines. The analytical method was based on an innovative application of solid phase extraction (SPE), followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using a triple quadrupole analyzer. The ground-breaking approach of SPE consists in the use of Oasis (R) MCX cartridges to pre-concentrate 500 mL of water samples, allowing the simultaneous extraction of acidic, basic and neutral analytes, rather than the conventional recovery of basic compounds only. Two chiral columns were used for enantiomeric separation in reverse elution mode, a Chirobiotic (TM) V and a Pirkle type Whelk-O (R) 1, for basic and acidic compounds, respectively. The method validation demonstrated good linearity (r(2) > 0.99), selectivity and sensitivity, with method detection limits between 0.01 and 2.66 ng L-1 and method quantification limits between 0.02 and 5.71 ng L-1. The developed method was successfully applied to monitor daily variations along one week in surface waters collected in 5 locations of the Douro River estuary. Tramadol (TRM) and its metabolite N-desmethyltramadol (NDT), presented high concentrations near the affluent of a tributary river, while the second eluted enantiomer of O-desmethyltramadol (ODT) was found at high concentrations at the mouth of the Douro River. The metabolite NDT was quantified at higher concentrations than TRM. Venlafaxine (VNF) was found at high concentrations near the affluent of the same tributary river, but its metabolite, O-desmethylvenlafaxine (ODV), was found at concentrations 3 times higher. COC was found every day at all sampling points along the estuary, with slight variations. (C) 2019 Elsevier B.V. All rights reserved.
英文关键词	Enantiomeric fraction Chiral columns Illegal drug Pharmaceutical Wastewater River water
类型	Article
语种	英语
国家	Portugal
收录类别	SCI-E
WOS记录号	WOS:000466831900012
WOS关键词	RESIDUE ENANTIOMERIC ANALYSIS ; WASTE-WATER ; LIQUID-CHROMATOGRAPHY ; ILLICIT DRUGS ; PHARMACEUTICALS ; METABOLITES ; AFRICAN ; ABUSE ; BASIN
WOS类目	Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217272
作者单位	1.CESPU, Inst Invest & Formacao Avancada Ciencias & Tecnol, Rua Cent Gandra 1317, P-4585116 Gandra Prd, Portugal; 2.Univ Porto, Lab Quim Organ & Farmaceut, Dept Ciencias Quim, Fac Farm, Rua Jorge de Viterbo Ferreira 228, P-4050313 Porto, Portugal; 3.Univ Porto, Fac Engn, LSRE LCM, Rua Dr Roberto Frias S-N, P-4200465 Porto, Portugal; 4.Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental C, Ave Gen Norton de Matos S-N, P-4450208 Matosinhos, Portugal
推荐引用方式 GB/T 7714	Coelho, Maria Miguel,Lado Ribeiro, Ana Rita,Sousa, Joao C. G.,et al. Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: Monitoring in Douro River estuary[J],2019,170:89-101.
APA	Coelho, Maria Miguel.,Lado Ribeiro, Ana Rita.,Sousa, Joao C. G..,Ribeiro, Claudia.,Fernandes, Carla.,...&Tiritan, Maria Elizabeth.(2019).Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: Monitoring in Douro River estuary.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,170,89-101.
MLA	Coelho, Maria Miguel,et al."Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: Monitoring in Douro River estuary".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 170(2019):89-101.