干旱区生态环境知识资源中心(Arid): Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples

Arid

DOI	10.1016/j.jpba.2018.12.047
	Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples
	Liang, Xiaoping 1; Hu, Ping 2; Zhang, Hongyang 2,3; Tan, Wen 1
通讯作者	Zhang, Hongyang ; Tan, Wen
来源期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
EISSN	1873-264X
出版年	2019
卷号	166 页码:379-386
英文摘要	In this work, hypercrosslinked strong anion-exchange polymer resins (HXLPP-SAX) were synthesized and evaluated as solid-phase extraction (SPE) sorbents for extracting fluoroquinolones (FQs) in milk samples. These particles were prepared using a protocol that was facile and cost-effective by combining hypercrosslinking reactions and quaternisation reactions in one step. After the synthesis, the morphological properties and anion-exchange, adsorption, and selectivity performances of the HXLPP-SAX resins were characterized and evaluated. It was shown that the polymers were monodisperse microspheres, with the mean diameters of 2-4 mu m, ion-exchange capacity (IEC) of 0.311 meq/g, and specific surface area more than 1000 m(2)/g. The resins applied as SPE sorbents possessed high selectivity in the extraction of amphoteric compounds (enoxacin and enrofloxacin as the representatives) followed by HPLC-UV analysis, as compared to commercially available strong anion-exchange sorbents (Oasis MAX). The SPE-HPLC-UV method was fully validated and exhibited good linearity (10-2000 ng/g, R-2 >= 0.997), low limits of detection (2.8-5.1 ng/g), good recoveries (85.8%-117.9%, RSDs <= 7.1%) and precisions (intra-day RSDs <= 7.7% and inter-day RSDs <= 9.4%). Then the method was performed the selective enrichment of six FQs (enoxacin, norfloxacin, ciprofloxacin, lomefloxacin, enrofloxacin, and sparfloxacin) in milk samples. The present results demonstrated that the proposed resins exhibited a promising potential for the enrichment and determination of FQ residues in milk samples as well as in other samples with complex matrices. (C) 2018 Published by Elsevier B.V.
英文关键词	Hypercrosslinked strong anion-exchange polymers Solid-phase extraction Trimethylamine modification Fluoroquinolones Milk
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000460713700044
WOS关键词	SOLID-PHASE EXTRACTION ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ILLICIT DRUGS ; MULTI-RESIDUE ; PHARMACEUTICALS ; ANTIBIOTICS ; CHARACTER ; WATER ; QUANTIFICATION ; CONTAMINATION
WOS类目	Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217270
作者单位	1.Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China; 3.East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Liang, Xiaoping,Hu, Ping,Zhang, Hongyang,et al. Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples[J],2019,166:379-386.
APA	Liang, Xiaoping,Hu, Ping,Zhang, Hongyang,&Tan, Wen.(2019).Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,166,379-386.
MLA	Liang, Xiaoping,et al."Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 166(2019):379-386.