干旱区生态环境知识资源中心(Arid): Computational Sequence Analysis of Inversion Breakpoint Regions in the Cactophilic Drosophila mojavensis Lineage

Arid

DOI	10.1093/jhered/esy057
	Computational Sequence Analysis of Inversion Breakpoint Regions in the Cactophilic Drosophila mojavensis Lineage
	Delprat, Alejandra; Guillen, Yolanda; Ruiz, Alfredo
通讯作者	Ruiz, Alfredo
来源期刊	JOURNAL OF HEREDITY
ISSN	0022-1503
EISSN	1465-7333
出版年	2019
卷号	110 期号:1 页码:102-117
英文摘要	We investigated rates of chromosomal evolution in Drosophila mojavensis using whole-genome sequence information from D. mojavensis, Drosophila buzzatii, and Drosophila virilis. Drosophila mojavensis is a cactophilic species of the repleta group living under extreme ecological conditions in the deserts of the Southwestern United States and Northwestern Mexico. The genome of D. buzzatii, another member of the repleta group, was recently sequenced and the largest scaffolds anchored to all chromosomes using diverse procedures. Chromosome organization between D. mojavensis and D. buzzatii was compared using MUMmer and GRIMM software. Our results corroborate previous cytological analyses that indicated chromosome 2 differed between these 2 species by 10 inversions, chromosomes X and 5 differed by one inversion each, and chromosome 4 was homosequential. In contrast, we found that chromosome 3 differed by 5 inversions instead of the expected 2 that were previously inferred by cytological analyses. Thirteen of these inversions occurred in the D. mojavensis lineage: 12 are fixed and one of them is a polymorphic inversion previously described in populations from Sonora and Baja California, Mexico. We previously investigated the breakpoints of chromosome 2 inversions fixed in D. mojavensis. Here we characterized the breakpoint regions of the 5 inversions found in chromosome 3 in order to infer the molecular mechanism that generated each inversion and its putative functional consequences. Overall, our results reveal a number of gene alterations at the inversion breakpoints with putative adaptive consequences that point to natural selection as the cause for fast chromosomal evolution in D. mojavensis.
英文关键词	cactophilic Drosophila fixation of rearrangements generation of inversions inversion breakpoints paracentric inversions
类型	Article
语种	英语
国家	Spain
收录类别	SCI-E
WOS记录号	WOS:000461519200010
WOS关键词	DEHYDROGENASE ADH PARALOGS ; HAT TRANSPOSABLE ELEMENTS ; X-CHROMOSOME ; POLYMORPHIC INVERSION ; EVOLUTIONARY HISTORY ; POLYTENE CHROMOSOMES ; POPULATION-GENETICS ; NATURAL-SELECTION ; THERMAL-STRESS ; CROSSING-OVER
WOS类目	Evolutionary Biology ; Genetics & Heredity
WOS研究方向	Evolutionary Biology ; Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217108
作者单位	Univ Autonoma Barcelona, Dept Genet & Microbiol, Bellaterra 08193, Barcelona, Spain
推荐引用方式 GB/T 7714	Delprat, Alejandra,Guillen, Yolanda,Ruiz, Alfredo. Computational Sequence Analysis of Inversion Breakpoint Regions in the Cactophilic Drosophila mojavensis Lineage[J],2019,110(1):102-117.
APA	Delprat, Alejandra,Guillen, Yolanda,&Ruiz, Alfredo.(2019).Computational Sequence Analysis of Inversion Breakpoint Regions in the Cactophilic Drosophila mojavensis Lineage.JOURNAL OF HEREDITY,110(1),102-117.
MLA	Delprat, Alejandra,et al."Computational Sequence Analysis of Inversion Breakpoint Regions in the Cactophilic Drosophila mojavensis Lineage".JOURNAL OF HEREDITY 110.1(2019):102-117.