Arid
DOI10.3390/jof5030074
First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk
Hamm, Paris S.1; Hutchison, Miriam, I1; Leonard, Pascale2; Melman, Sandra3; Natvig, Donald O.1
通讯作者Natvig, Donald O.
来源期刊JOURNAL OF FUNGI
EISSN2309-608X
出版年2019
卷号5期号:3
英文摘要Coccidioidomycosis (Valley Fever) is a disease caused by species of Coccidioides. The disease is endemic to arid regions of the Southwestern US and while most common in CA and AZ is also present in NM. We present the first genetic analysis of clinical isolates from NM. Travel and demographic information was available for a number of patients, which included individuals from NM and the Southwestern US Four Corners region. Multi-gene phylogenetic analyses revealed the presence of both C. posadasii and C. immitis. While NM is predicted to be within the endemic range for C. posadasii, our results expand the known range of C. immitis, often considered to be the California species. Five of eight infections for which patient ethnicity existed occurred in Native Americans, and two occurred in African Americans. Several isolates came from the northwestern part of NM-outside the predicted highly-endemic region. Our study suggests Native Americans represent an unrecognized at-risk group, and it provides a foundation for better defining the geographic distribution of the Coccidioides species and for preventing exposure among populations at risk. In the course of this study, we developed a reliable PCR-based method to distinguish species targeting regions of the mitochondrial genome.
英文关键词Coccidioides coccidioidomycosis New Mexico American Indian Valley Fever
类型Article
语种英语
国家USA
开放获取类型Green Published, gold, Green Submitted
收录类别SCI-E
WOS记录号WOS:000488001200032
WOS关键词POPULATION ; ARIZONA ; GENETICS ; CYCLE ; DNA
WOS类目Microbiology ; Mycology
WOS研究方向Microbiology ; Mycology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/217024
作者单位1.Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA;
2.New Mexico Dept Hlth, Sci Lab Div, 1101 Camino Salud NE, Albuquerque, NM 87102 USA;
3.New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM 87505 USA
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GB/T 7714
Hamm, Paris S.,Hutchison, Miriam, I,Leonard, Pascale,et al. First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk[J],2019,5(3).
APA Hamm, Paris S.,Hutchison, Miriam, I,Leonard, Pascale,Melman, Sandra,&Natvig, Donald O..(2019).First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk.JOURNAL OF FUNGI,5(3).
MLA Hamm, Paris S.,et al."First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk".JOURNAL OF FUNGI 5.3(2019).
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