Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.3390/jof5030074 |
First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk | |
Hamm, Paris S.1; Hutchison, Miriam, I1; Leonard, Pascale2; Melman, Sandra3; Natvig, Donald O.1 | |
通讯作者 | Natvig, Donald O. |
来源期刊 | JOURNAL OF FUNGI
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EISSN | 2309-608X |
出版年 | 2019 |
卷号 | 5期号:3 |
英文摘要 | Coccidioidomycosis (Valley Fever) is a disease caused by species of Coccidioides. The disease is endemic to arid regions of the Southwestern US and while most common in CA and AZ is also present in NM. We present the first genetic analysis of clinical isolates from NM. Travel and demographic information was available for a number of patients, which included individuals from NM and the Southwestern US Four Corners region. Multi-gene phylogenetic analyses revealed the presence of both C. posadasii and C. immitis. While NM is predicted to be within the endemic range for C. posadasii, our results expand the known range of C. immitis, often considered to be the California species. Five of eight infections for which patient ethnicity existed occurred in Native Americans, and two occurred in African Americans. Several isolates came from the northwestern part of NM-outside the predicted highly-endemic region. Our study suggests Native Americans represent an unrecognized at-risk group, and it provides a foundation for better defining the geographic distribution of the Coccidioides species and for preventing exposure among populations at risk. In the course of this study, we developed a reliable PCR-based method to distinguish species targeting regions of the mitochondrial genome. |
英文关键词 | Coccidioides coccidioidomycosis New Mexico American Indian Valley Fever |
类型 | Article |
语种 | 英语 |
国家 | USA |
开放获取类型 | Green Published, gold, Green Submitted |
收录类别 | SCI-E |
WOS记录号 | WOS:000488001200032 |
WOS关键词 | POPULATION ; ARIZONA ; GENETICS ; CYCLE ; DNA |
WOS类目 | Microbiology ; Mycology |
WOS研究方向 | Microbiology ; Mycology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/217024 |
作者单位 | 1.Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA; 2.New Mexico Dept Hlth, Sci Lab Div, 1101 Camino Salud NE, Albuquerque, NM 87102 USA; 3.New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM 87505 USA |
推荐引用方式 GB/T 7714 | Hamm, Paris S.,Hutchison, Miriam, I,Leonard, Pascale,et al. First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk[J],2019,5(3). |
APA | Hamm, Paris S.,Hutchison, Miriam, I,Leonard, Pascale,Melman, Sandra,&Natvig, Donald O..(2019).First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk.JOURNAL OF FUNGI,5(3). |
MLA | Hamm, Paris S.,et al."First Analysis of Human Coccidioides Isolates from New Mexico and the Southwest Four Corners Region: Implications for the Distributions of C. posadasii and C. immitis and Human Groups at Risk".JOURNAL OF FUNGI 5.3(2019). |
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