干旱区生态环境知识资源中心(Arid): A LC-MS/MS method for the determination of common synthetic cathinones in meconium

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DOI	10.1016/j.jchromb.2019.06.030
	A LC-MS/MS method for the determination of common synthetic cathinones in meconium
	Lopez-Rabunal, Angela 1; Lendoiro, Elena 1; Concheiro, Marta 2; Lopez-Rivadulla, Manuel 1; Cruz, Angelines 1; de-Castro-Rios, Ana 1
通讯作者	de-Castro-Rios, Ana
来源期刊	JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN	1570-0232
EISSN	1873-376X
出版年	2019
卷号	1124 页码:349-355
英文摘要	New psychoactive substances have been introduced into the market in the last years due to their unregulated status. Synthetic cathinones are one of their main representatives, and they have shown to produce neonatal complications. It is important to have objective tools to identify in utero exposure to drugs that have shown to produce neonatal complications. An analytical method was developed and fully validated for the determination of common synthetic cathinones, including methylone, methedrone, mephedrone, 3,4-methylenedioxypyrovalerone (MDPV), ( +/- )-4-fluoromethamphetamine and 4-fluoromethcathinone in meconium. Meconium (0.25 +/- 0.02 g) was homogenized with methanol by sonication for 30 min. After centrifugation, the sample was extracted with Oasis MCX columns. The analysis was performed by LC-MS/MS using an Atlantis T3 column (3 mu m, 2.1 x 50 mm) and a gradient with acetonitrile and 0.1% formic acid in water. Method validation included the following parameters: selectivity (no endogenous or exogenous interferences), limits of detection (n = 3, 0.5-1 ng/g) and quantification (n = 3, 1-2 ng/g), linearity (n = 5, LOQ 200 ng/g), imprecision (n = 15, 0% to 10%), accuracy (n = 15, 87.3% to 97.8%), matrix effect (n = 10, -76% to - 28.1%), extraction efficiency (n = 6, 63.7% to 91.3%), total process efficiency (n = 6, 16% to 60.2%) and stability for 72 h in the autosampler (n = 3, %loss = -6.7% to 5.1%). The method was applied to 28 meconium specimens.
英文关键词	Synthetic cathinones New psychoactive substances Meconium In utero drug exposure LC-MS/MS
类型	Article
语种	英语
国家	Spain ; USA
收录类别	SCI-E
WOS记录号	WOS:000477685600040
WOS关键词	MASS-SPECTROMETRY DETERMINATION ; DESIGNER DRUGS ; SCREENING METHOD ; URINE ; STIMULANTS ; HAIR ; DERIVATIVES ; TOXICOLOGY ; PREGNANCY ; SAMPLES
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/216845
作者单位	1.Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Serv Toxicol, San Francisco S-N, Santiago De Compostela 15782, Spain; 2.CUNY John Jay Coll Criminal Justice, New York, NY 10019 USA
推荐引用方式 GB/T 7714	Lopez-Rabunal, Angela,Lendoiro, Elena,Concheiro, Marta,et al. A LC-MS/MS method for the determination of common synthetic cathinones in meconium[J],2019,1124:349-355.
APA	Lopez-Rabunal, Angela,Lendoiro, Elena,Concheiro, Marta,Lopez-Rivadulla, Manuel,Cruz, Angelines,&de-Castro-Rios, Ana.(2019).A LC-MS/MS method for the determination of common synthetic cathinones in meconium.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1124,349-355.
MLA	Lopez-Rabunal, Angela,et al."A LC-MS/MS method for the determination of common synthetic cathinones in meconium".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1124(2019):349-355.