干旱区生态环境知识资源中心(Arid): Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis

Arid

DOI	10.1111/ijd.14238
	Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis
	Brewer, Ann C.1; Huber, Jordan T.2; Girardo, Marlene E.3; Kosiorek, Heidi E.3; Burns, Mark W.4; Stewart, Terry D.5; Blair, Janis E.4
通讯作者	Blair, Janis E.
来源期刊	INTERNATIONAL JOURNAL OF DERMATOLOGY
ISSN	0011-9059
EISSN	1365-4632
出版年	2019
卷号	58 期号:2 页码:250-253
英文摘要	Background Fluconazole is the most commonly used antifungal treatment for various forms of coccidioidomycosis. Although we had anecdotally observed a high proportion of patients reporting cutaneous adverse effects associated with fluconazole treatment, this observation was not well described in the medical literature, and we were unsure of the additional effect of the arid desert environment of Arizona. Methods We performed a one-time, voluntary survey of patients with coccidioidomycosis and compared the responses of patients treated with fluconazole with those of untreated patients. Results From January 1, 2015, to August 22, 2017, 62 fluconazole-treated and 35 untreated patients with coccidioidomycosis provided consent and were enrolled in the study; demographics were similar between the two groups. Among the 62 fluconazole-treated patients, daily dosages ranged from 200 mg to 800 mg. However, most (44/62, 71%) took 400 mg daily, the typical dose for the treatment of coccidioidomycosis. The median fluconazole treatment duration at the time of study participation was 6 months. When compared with untreated patients, those taking fluconazole had more moderate to severe dry lips (74.2% [46/62] vs. 23.5% [8/34]; P < 0.001), dry skin (45.8% [27/59] vs. 22.9% [8/35]; P = 0.03), and alopecia (31.1% [19/61] vs. 11.4% [4/35]; P = 0.004). Conclusions For the treatment of coccidioidomycosis, patients receiving fluconazole reported significantly more severe cutaneous effects, including dry lips, dry skin, and alopecia, than untreated patients. Our findings identify an association but do not prove causality.
类型	Article
语种	英语
国家	USA
收录类别	SCI-E
WOS记录号	WOS:000455042700033
WOS关键词	POPULATION ; SKIN
WOS类目	Dermatology
WOS研究方向	Dermatology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/216400
作者单位	1.Dermatol Associates, Kalispell, MT USA; 2.Mayo Clin Hosp, Dept Dermatol, Phoenix, AZ USA; 3.Mayo Clin, Biostat, Scottsdale, AZ USA; 4.Mayo Clin Hosp, Div Infect Dis, 5777 E Mayo Blvd, Phoenix, AZ 85054 USA; 5.Mayo Clin Global Business Solut, Rochester, MN USA
推荐引用方式 GB/T 7714	Brewer, Ann C.,Huber, Jordan T.,Girardo, Marlene E.,et al. Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis[J],2019,58(2):250-253.
APA	Brewer, Ann C..,Huber, Jordan T..,Girardo, Marlene E..,Kosiorek, Heidi E..,Burns, Mark W..,...&Blair, Janis E..(2019).Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis.INTERNATIONAL JOURNAL OF DERMATOLOGY,58(2),250-253.
MLA	Brewer, Ann C.,et al."Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis".INTERNATIONAL JOURNAL OF DERMATOLOGY 58.2(2019):250-253.