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DOI	10.1016/j.ijbiomac.2018.12.204
	Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl
	Marei, Narguess 1; Elwahy, Ahmed H. M.1; Salah, Taher A.2; El Sherif, Youssef 3; Abd El-Samie, Emtithal 4
通讯作者	Abd El-Samie, Emtithal
来源期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
EISSN	1879-0003
出版年	2019
卷号	126 页码:262-272
英文摘要	Chitosan (CS), possess enormous properties, being biodegradable, biocompatible, and antimicrobial. CS could be formulated and casted into different forms including 2D films, hydrogels, and nanoparticles. Chitosan-based nanoparticles (CSNPs) showed countless interest as polymeric drug delivery system (DDS) with its improved bioavailability, and stability when compared with traditional DDS. Ciprofloxacin is a prescribed antibiotic for many diseases, but its efficiency was affected by antibacterial resistance. Therefore, in this study, CSNPs loaded with ciprofloxacin (Cipro/CSNPs) were prepared from CS isolated from desert locusts, beetles, honey bee exoskeletons, and shrimp shells were used as a standard control. CSNPs were formulated by ionic crosslinking method, then loaded with ciprofloxacin HCl, and characterized using particle size distribution, zeta potential, and drug entrapment efficiency. The release of ciprofloxacin from CSNPs was evaluated and its kinetic modelling was performed. Antibacterial activity of CSNPs was evaluated against Escherichia coli, Bacillus thuringiensis, Methicillin-resistant Staphylococcus aureus (MRSA) and, Pseudomonas aeruginosa. Minimum inhibitory concentrations (MIC) were determined and compared between chitosan sources. The Cipro/CSNPs results indicate that the highest antibacterial activity against E. coli and MRSA with MIC varying from 0.0043 to 0.01 mu g/ml and from 0.07 to 0.14 mu g/ml, respectively. In addition, CSNPs enhanced drug delivery, and allowed its controlled release. (C) 2018 Published by Elsevier B.V.
英文关键词	Chitosan nanoparticles Antibacterial activity Drug delivery
类型	Article
语种	英语
国家	Egypt
收录类别	SCI-E
WOS记录号	WOS:000460710000031
WOS关键词	DRUG-DELIVERY-SYSTEM ; PHYSICOCHEMICAL CHARACTERIZATION ; ANTIMICROBIAL ACTIVITY ; POTENTIAL APPLICATIONS ; RESTING EGGS ; CHITIN ; RELEASE ; EXTRACTION ; MECHANISM ; NANOMATERIALS
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/216356
作者单位	1.Cairo Univ, Chem Dept, Fac Sci, Giza, Egypt; 2.British Univ Egypt, Nanotechnol Res Ctr, Cairo, Egypt; 3.Heliopolis Univ, Fac Pharm, Dept Pharmaceut & Drug Technol, Cairo, Egypt; 4.Cairo Univ, Entomol Dept, Fac Sci, Giza, Egypt
推荐引用方式 GB/T 7714	Marei, Narguess,Elwahy, Ahmed H. M.,Salah, Taher A.,et al. Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl[J],2019,126:262-272.
APA	Marei, Narguess,Elwahy, Ahmed H. M.,Salah, Taher A.,El Sherif, Youssef,&Abd El-Samie, Emtithal.(2019).Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,126,262-272.
MLA	Marei, Narguess,et al."Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 126(2019):262-272.