干旱区生态环境知识资源中心(Arid): RNA Interference in Insects: Protecting Beneficials and Controlling Pests

Arid

DOI	10.3389/fphys.2018.01912
	RNA Interference in Insects: Protecting Beneficials and Controlling Pests
	Vogel, Elise; Santos, Dulce; Mingels, Lina; Verdonckt, Thomas-Wolf; Vanden Broeck, Jozef
通讯作者	Vogel, Elise ; Santos, Dulce
来源期刊	FRONTIERS IN PHYSIOLOGY
ISSN	1664-042X
出版年	2019
卷号	9
英文摘要	Insects constitute the largest and most diverse group of animals on Earth with an equally diverse virome. The main antiviral immune system of these animals is the post-transcriptional gene-silencing mechanism known as RNA(i) interference. Furthermore, this process can be artificially triggered via delivery of gene-specific double-stranded RNA molecules, leading to specific endogenous gene silencing. This is called RNAi technology and has important applications in several fields. In this paper, we review RNAi mechanisms in insects as well as the potential of RNAi technology to contribute to species-specific insecticidal strategies. Regarding this aspect, we cover the range of strategies considered and investigated so far, as well as their limitations and the most promising approaches to overcome them. Additionally, we discuss patterns of viral infection, specifically persistent and acute insect viral infections. In the latter case, we focus on infections affecting economically relevant species. Within this scope, we review the use of insect-specific viruses as bio-insecticides. Last, we discuss RNAi-based strategies to protect beneficial insects from harmful viral infections and their potential practical application. As a whole, this manuscript stresses the impact of insect viruses and RNAi technology in human life, highlighting clear lines of investigation within an exciting and promising field of research.
英文关键词	insects RNA interference environmental RNAi systemic RNAi insecticides delivery systems viruses antiviral immunity
类型	Review
语种	英语
国家	Belgium
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000455548000001
WOS关键词	DOUBLE-STRANDED-RNA ; WESTERN CORN-ROOTWORM ; CYTOPLASMIC POLYHEDROSIS-VIRUS ; INFECTIOUS MYONECROSIS VIRUS ; CELL-PENETRATING PEPTIDES ; ACUTE PARALYSIS VIRUS ; APIS-MELLIFERA L. ; DESERT LOCUST ; SACBROOD VIRUS ; AEDES-AEGYPTI
WOS类目	Physiology
WOS研究方向	Physiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215817
作者单位	Katholieke Univ Leuven, Res Grp Mol Dev Physiol & Signal Transduct, Leuven, Belgium
推荐引用方式 GB/T 7714	Vogel, Elise,Santos, Dulce,Mingels, Lina,et al. RNA Interference in Insects: Protecting Beneficials and Controlling Pests[J],2019,9.
APA	Vogel, Elise,Santos, Dulce,Mingels, Lina,Verdonckt, Thomas-Wolf,&Vanden Broeck, Jozef.(2019).RNA Interference in Insects: Protecting Beneficials and Controlling Pests.FRONTIERS IN PHYSIOLOGY,9.
MLA	Vogel, Elise,et al."RNA Interference in Insects: Protecting Beneficials and Controlling Pests".FRONTIERS IN PHYSIOLOGY 9(2019).