干旱区生态环境知识资源中心(Arid): Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves

Arid

DOI	10.3389/fnmol.2019.00069
	Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves
	Jessen, Kristjan R.; Mirsky, Rhona
通讯作者	Jessen, Kristjan R.
来源期刊	FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN	1662-5099
出版年	2019
卷号	12
英文摘要	The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precursors (SCP) in early embryonic nerves, and immature Schwann cells (iSch) in late embryonic and perinatal nerves. SCP are formed when neural crest cells enter nascent nerves and form intimate relationships with axons, a diagnostic feature of glial cells. This involves large-scale changes in gene expression, including the activation of established glial cell markers. Like early glia in the CNS, radial glia, SCP retain developmental multipotency and contribute to other crest-derived lineages during embryonic development. SCP, as well as closely related cells termed boundary cap cells, and later stages of the Schwann cell lineage have all been implicated as the tumor initiating cell in NF1 associated neurofibromas. iSch are formed from SCP in a process that involves the appearance of additional differentiation markers, autocrine survival circuits, cellular elongation, a formation of endoneurial connective tissue and basal lamina. Finally, in peri-and post-natal nerves, iSch are reversibly induced by axon-associated signals to form the myelin and non-myelin Schwann cells of adult nerves. This review article discusses early Schwann cell development in detail and describes a large number of molecular signaling systems that control glial development in embryonic nerves.
英文关键词	Schwann cell precursor neural crest nerve development PNS Schwann cell lineage PNS glia multipotent glia
类型	Review
语种	英语
国家	England
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000462608300001
WOS关键词	BOUNDARY CAP CELLS ; CREST STEM-CELLS ; TRANSCRIPTION FACTOR SOX10 ; NEURAL CREST ; PERIPHERAL-NERVES ; NERVOUS-SYSTEM ; GROWTH-FACTOR ; IN-VITRO ; NEURONAL DIFFERENTIATION ; DESERT-HEDGEHOG
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215813
作者单位	UCL, Dept Cell & Dev Biol, London, England
推荐引用方式 GB/T 7714	Jessen, Kristjan R.,Mirsky, Rhona. Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves[J]. University of London,2019,12.
APA	Jessen, Kristjan R.,&Mirsky, Rhona.(2019).Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves.FRONTIERS IN MOLECULAR NEUROSCIENCE,12.
MLA	Jessen, Kristjan R.,et al."Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves".FRONTIERS IN MOLECULAR NEUROSCIENCE 12(2019).