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| DOI | 10.3389/fimmu.2019.02188 |
| The Rise of Coccidioides: Forces Against the Dust Devil Unleashed | |
| Van Dyke, Marley C. Caballero1; Thompson, George R., III2,3; Galgiani, John N.4; Barker, Bridget M.1 | |
| 通讯作者 | Barker, Bridget M. |
| 来源期刊 | FRONTIERS IN IMMUNOLOGY
 |
| ISSN | 1664-3224 |
| 出版年 | 2019 |
| 卷号 | 10 |
| 英文摘要 | Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against Coccidioides infection. In this review, we discuss the battle against Coccidioides including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to Coccidioides infection. |
| 英文关键词 | Coccidioides valley fever fungal vaccines antifungal drugs immunity |
| 类型 | Review |
| 语种 | 英语 |
| 国家 | USA |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000485181800001 |
| WOS关键词 | LIPOSOMAL AMPHOTERICIN-B ; IN-VITRO ACTIVITY ; CD8(+) T-CELLS ; INFECTIOUS-DISEASES SOCIETY ; VACCINE-INDUCED PROTECTION ; BROAD-SPECTRUM ANTIFUNGAL ; DENDRITIC CELLS ; CEREBROSPINAL-FLUID ; REFRACTORY COCCIDIOIDOMYCOSIS ; MURINE MODEL |
| WOS类目 | Immunology |
| WOS研究方向 | Immunology |
| 来源机构 | University of Arizona ; University of California, Davis |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/215774 |
| 作者单位 | 1.No Arizona Univ, Pathogen & Microbiome Inst, Flagstaff, AZ 86011 USA; 2.Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA; 3.Univ Calif Davis, Med Ctr, Dept Internal Med, Div Infect Dis, Sacramento, CA 95817 USA; 4.Univ Arizona, Coll Med Tucson, Dept Med, Valley Fever Ctr Excellence, Tucson, AZ USA |
| 推荐引用方式 GB/T 7714 | Van Dyke, Marley C. Caballero,Thompson, George R., III,Galgiani, John N.,et al. The Rise of Coccidioides: Forces Against the Dust Devil Unleashed[J]. University of Arizona, University of California, Davis,2019,10. |
| APA | Van Dyke, Marley C. Caballero,Thompson, George R., III,Galgiani, John N.,&Barker, Bridget M..(2019).The Rise of Coccidioides: Forces Against the Dust Devil Unleashed.FRONTIERS IN IMMUNOLOGY,10. |
| MLA | Van Dyke, Marley C. Caballero,et al."The Rise of Coccidioides: Forces Against the Dust Devil Unleashed".FRONTIERS IN IMMUNOLOGY 10(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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