干旱区生态环境知识资源中心(Arid): Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels

Arid

DOI	10.3389/fgene.2019.00893
	Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels
	Bahbahani, Hussain 1; Musa, Hassan H.2; Wragg, David 3; Shuiep, Eltahir S.4; Almathen, Faisal 5; Hanotte, Olivier 6
通讯作者	Bahbahani, Hussain ; Musa, Hassan H.
来源期刊	FRONTIERS IN GENETICS
EISSN	1664-8021
出版年	2019
卷号	10
英文摘要	Dromedary camels (Camelus dromedarius) are single-humped animals found throughout the deserts of Africa, the Arabian Peninsula, and the southwest of Asia. This well-adapted species is mainly used for milk and meat production, although some specific types exhibit superior running performance and are used in racing competitions. However, neither performance nor production camels are bred under intensive genomic selection programs with specific aims to improve these traits. In this study, the full genome sequence data of six camels from the Arabian Peninsula and the genotyping-by-sequencing data of 44 camels (29 packing and 15 racing) from Sudan were analyzed to assess their genome diversities, relationships, and candidate signatures of positive selection. Genome ADMIXTURE and principle component analyses indicate clear geographic separation between the Sudanese and the Arabian Peninsula camels, but with no population-specific genetic distinction within populations. Camel samples from the Arabian Peninsula show higher mean heterozygosity (0.560 +/- 0.003) than those from Sudan (0.347 +/- 0.003). Analyses of signatures of selection, using pooled heterozygosity (Hp) approach, in the Sudanese camels revealed 176, 189, and 308 candidate regions under positive selection in the combined and packing and racing camel populations, respectively. These regions host genes that might be associated with adaptation to arid environment, dairy traits, energy homeostasis, and chondrogenesis. Eight regions show high genetic differentiation, based on Fst analysis, between the Sudanese packing and racing camel types. Genes associated with chondrogenesis, energy balance, and urinary system development were found within these regions. Our results advocate for further detailed investigation of the genome of the dromedary camel to identify and characterize genes and variants associated with their valuable phenotypic traits. The results of which may support the development of breeding programs to improve the production and performance traits of this unique domesticated species.
英文关键词	genotype-by-sequence positive selection milk production racing camels Arabian Peninsula Sudan
类型	Article
语种	英语
国家	Kuwait ; Sudan ; Scotland ; Saudi Arabia ; Ethiopia
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000487299200001
WOS关键词	MOLECULAR CHARACTERIZATION ; OLFACTORY RECEPTOR ; GENETIC DIVERSITY ; LONG-READ ; ASSOCIATION ; DENSITY ; POPULATIONS ; EXPRESSION ; FRAMEWORK ; DYNAMICS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215773
作者单位	1.Kuwait Univ, Fac Sci, Dept Biol Sci, Kuwait, Kuwait; 2.Univ Khartoum, Fac Med Lab Sci, Dept Med Microbiol, Khartoum, Sudan; 3.Roslin Inst, Ctr Trop Livestock Genet & Hlth, Edinburgh, Midlothian, Scotland; 4.Univ Gadarif, Fac Agr & Environm Sci, Dept Anim Prod, Gadarif, Gadarif State, Sudan; 5.King Faisal Univ, Coll Vet Med, Dept Publ Hlth, Al Hasa, Saudi Arabia; 6.ILRI, LiveGene, Addis Ababa, Ethiopia
推荐引用方式 GB/T 7714	Bahbahani, Hussain,Musa, Hassan H.,Wragg, David,et al. Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels[J],2019,10.
APA	Bahbahani, Hussain,Musa, Hassan H.,Wragg, David,Shuiep, Eltahir S.,Almathen, Faisal,&Hanotte, Olivier.(2019).Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels.FRONTIERS IN GENETICS,10.
MLA	Bahbahani, Hussain,et al."Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels".FRONTIERS IN GENETICS 10(2019).