干旱区生态环境知识资源中心(Arid): Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle

Arid

DOI	10.3389/fgene.2019.00609
	Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle
	Alshawi, Akil 1,2; Essa, Abdulameer 3; Al-Bayatti, Sahar 3; Hanotte, Olivier 1,4
通讯作者	Alshawi, Akil
来源期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
出版年	2019
卷号	10
英文摘要	The Near East cattle are adapted to different agro-ecological zones including desert areas, mountains habitats, and humid regions along the Tigris and Euphrates rivers system. The region was one of the earliest and most significant areas of cattle husbandry. Currently, four main breeds of Iraqi cattle are recognized. Among these, the Jenoubi is found in the southern more humid part of Iraq, while the Rustaqi is found in the middle and drier region of the country. Despite their importance, Iraqi cattle have up to now been poorly characterized at the genome level. Here, we report at a genome-wide level the diversity and signature of positive selection in these two breeds. Thirty-five unrelated Jenoubi cattle, sampled in the Maysan and Basra regions, and 60 Rustaqi cattle, from around Baghdad and Babylon, were genotyped using the Illumine Bovine HD BeadChip (700K). Genetic population structure and diversity level were studied using principal component analysis (PCA), expected heterozygosity (He), observed heterozygosity (Ho), and admixture. Signatures of selection were studied using extended haplotype homozygosity (EHH) (iHS and Rsb) and inter-population Wright's Fst. The results of PCA and admixture analysis, including European taurine, Asian indicine, African indicine, and taurine indicate that the two breeds are crossbreed zebu X taurine, with more zebu background in Jenoubi cattle compared with Rustaqi. The Rustaqi has the greatest mean heterozygosity (He = 0.37) among all breeds. iHS and Rsb signatures of selection analyses identify 68 candidate genes under positive selection in the two Iraqi breeds, while Fst analysis identifies 220 candidate genes including genes related to the innate and acquired immunity responses, different environmental selection pressures (e.g., tick resistance and heat stress), and genes of commercial interest (e.g., marbling score).
英文关键词	Bos taurus Bos indicus genetic structure diversity positive selection immune responses adaptive genes
类型	Article
语种	英语
国家	England ; Iraq ; Ethiopia
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000475947400001
WOS关键词	RECENT POSITIVE SELECTION ; DOMESTIC CATTLE ; CANDIDATE GENES ; MILK-PRODUCTION ; ASSOCIATION ; EXPRESSION ; RESOURCES ; ORIGINS ; NUMBER ; IDENTIFICATION
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215772
作者单位	1.Univ Nottingham, Fac Med & Hlth Sci, Sch Life Sci, Div Cells Organisms & Mol Genet, Univ Pk Campus, Nottingham, England; 2.Univ Baghdad, Dept Internal & Prevent Vet Med, Coll Vet Med, Iraqi Minist Higher Educ & Sci Res, Baghdad, Iraq; 3.Minist Iraqi Agr, Directorate Anim Resources, Anim Genet Resources Dept, Baghdad, Iraq; 4.ILRI, LiveGene, Addis Ababa, Ethiopia
推荐引用方式 GB/T 7714	Alshawi, Akil,Essa, Abdulameer,Al-Bayatti, Sahar,et al. Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle[J],2019,10.
APA	Alshawi, Akil,Essa, Abdulameer,Al-Bayatti, Sahar,&Hanotte, Olivier.(2019).Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle.FRONTIERS IN GENETICS,10.
MLA	Alshawi, Akil,et al."Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle".FRONTIERS IN GENETICS 10(2019).