干旱区生态环境知识资源中心(Arid): The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients

Arid

DOI	10.3389/fgene.2019.00591
	The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients
	Khan, Haris A.; Margulies, Carla E.
通讯作者	Margulies, Carla E.
来源期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
出版年	2019
卷号	10
英文摘要	Our ability to overcome the challenges behind metabolic disorders will require a detailed understanding of the regulation of responses to nutrition. The Creb3 transcription factor family appears to have a unique regulatory role that links cellular secretory capacity with development, nutritional state, infection, and other stresses. This role in regulating individual secretory capacity genes could place this family of transcription factors at an important regulatory intersection mediating an animal's responses to nutrients and other environmental challenges. Interestingly, in both humans and mice, individuals with mutations in Creb3L3/CrebH, one of the Creb3 family members, exhibit hypertriglyceridemia (HTG) thus linking this transcription factor to lipid metabolism. We are beginning to understand how Creb3L3 and related family members are regulated and to dissect the potential redundancy and cross talk between distinct family members, thereby mediating both healthy and pathological responses to the environment. Here, we review the current knowledge on the regulation of Creb3 family transcription factor activity, their target genes, and their role in metabolic disease.
英文关键词	Creb3 metabolism transcription chromatin secretion metabolic disease
类型	Review
语种	英语
国家	Germany
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000472536600001
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; ELEMENT-BINDING PROTEIN ; LUMAN/CREB3 RECRUITMENT FACTOR ; CREB-H TRANSCRIPTION ; HOST-CELL FACTOR ; BODY-MASS INDEX ; OSTEOBLAST DIFFERENTIATION ; TRANSDUCER OASIS ; KEY REGULATOR ; FATTY-ACIDS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215771
作者单位	Ludwig Maximilians Univ Munchen, Physiol Chem, Biomed Ctr, Munich, Germany
推荐引用方式 GB/T 7714	Khan, Haris A.,Margulies, Carla E.. The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients[J],2019,10.
APA	Khan, Haris A.,&Margulies, Carla E..(2019).The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients.FRONTIERS IN GENETICS,10.
MLA	Khan, Haris A.,et al."The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients".FRONTIERS IN GENETICS 10(2019).