干旱区生态环境知识资源中心(Arid): Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions

Arid

DOI	10.3389/fgene.2018.00737
	Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions
	Walugembe, Muhammed 1; Bertolini, Francesca 1; Dematawewa, Chandraratne Mahinda B.2; Reis, Matheus P.3; Elbeltagy, Ahmed R.4; Schmidt, Carl J.5; Lamont, Susan J.1; Rothschild, Max F.1
通讯作者	Walugembe, Muhammed
来源期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
出版年	2019
卷号	9
英文摘要	Extreme environmental conditions are a major challenge in livestock production. Changes in climate, particularly those that contribute to weather extremes like drought or excessive humidity, may result in reduced performance and reproduction and could compromise the animal's immune function. Animal survival within extreme environmental conditions could be in response to natural selection and to artificial selection for production traits that over time together may leave selection signatures in the genome. The aim of this study was to identify selection signatures that may be involved in the adaptation of indigenous chickens from two different climatic regions (Sri Lanka = Tropical; Egypt = Arid) and in non-indigenous chickens that derived from human migration events to the generally tropical State of Sao Paulo, Brazil. To do so, analyses were conducted using fixation index (Fst) and hapFLK analyses. Chickens from Brazil (n = 156), Sri Lanka (n = 92), and Egypt (n = 96) were genotyped using the Affymetrix AxiomR (R) 600k Chicken Genotyping Array. Pairwise Fst analyses among countries did not detect major regions of divergence between chickens from Sri Lanka and Brazil, with ecotypes/breeds from Brazil appearing to be genetically related to Asian-Indian (Sri Lanka) ecotypes. However, several differences were detected in comparisons of Egyptian with either Sri Lankan or Brazilian populations, and common regions of difference on chromosomes 2, 3 and 8 were detected. The hapFLK analyses for the three separate countries suggested unique regions that are potentially under selection on chromosome 1 for all three countries, on chromosome 4 for Sri Lankan, and on chromosomes 3, 5, and 11 for the Egyptian populations. Some of identified regions under selection with hapFLK analyses contained genes such as TLR3, SOCS2, EOMES, and NFAT5 whose biological functions could provide insights in understanding adaptation mechanisms in response to arid and tropical environments.
英文关键词	chickens environment selection signatures adaptation immune system
类型	Article
语种	英语
国家	USA ; Sri Lanka ; Brazil ; Egypt
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000455670100001
WOS关键词	TOLL-LIKE RECEPTORS ; GENETIC DIVERSITY ; HIGH-ALTITUDE ; HEAT-STRESS ; CYTOKINE ; GENOME ; ADAPTATION ; EXPRESSION ; REVEALS ; SUPPRESSORS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215765
作者单位	1.Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA; 2.Univ Peradeniya, Dept Anim Sci, Fac Agr, Kandy, Sri Lanka; 3.Sao Paulo State Univ, Dept Anim Sci, Coll Agr & Vet Sci, Jaboticabal, Brazil; 4.Anim Prod Res Inst, Dept Anim Biotechnol, Giza, Egypt; 5.Univ Delaware, Anim & Food Sci, Newark, DE USA
推荐引用方式 GB/T 7714	Walugembe, Muhammed,Bertolini, Francesca,Dematawewa, Chandraratne Mahinda B.,et al. Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions[J],2019,9.
APA	Walugembe, Muhammed.,Bertolini, Francesca.,Dematawewa, Chandraratne Mahinda B..,Reis, Matheus P..,Elbeltagy, Ahmed R..,...&Rothschild, Max F..(2019).Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions.FRONTIERS IN GENETICS,9.
MLA	Walugembe, Muhammed,et al."Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions".FRONTIERS IN GENETICS 9(2019).