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DOI	10.1080/19440049.2019.1668968
	Perchlorate in human milk samples from the maternal-infant research on environmental chemicals study (MIREC)
	Wang, Zhongwen 1; Sparling, Melissa 1; Wang, Kuan Chiao 2; Arbuckle, Tye E.3; Fraser, William 4,5
通讯作者	Wang, Zhongwen
来源期刊	FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
ISSN	1944-0049
EISSN	1944-0057
出版年	2019
卷号	36 期号:12 页码:1837-1846
英文摘要	Perchlorate is a low molecular weight highly soluble anion. It occurs naturally in the environment, primarily near potash deposits and in arid regions. The determination of perchlorate in human milk is of interest in vulnerable populations such as infants and pregnant women. In this study, a sensitive and selective isotope dilution ion chromatography/tandem mass spectrometry (ID IC-MS/MS) method was developed and validated for the determination of perchlorate in human milk samples collected from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study. The limit of detection (LOD) was 0.27 mu g center dot kg(-1) for human milk. A total of 439 human milk samples were analysed with measurable levels of perchlorate in most of the milk samples, and the mean value was 7.62 +/- 32.7 mu g center dot kg(-1). This project provided important information related to perchlorate levels in human milk collected across Canada and the extent to which pregnant women and their infants may be exposed to perchlorate. A dietary exposure assessment was also conducted in infants based on the measured values in human milk. The mean perchlorate probable daily intakes (PDIs) for infants consuming human milk were 0.31 +/- 0.07 mu g/kg bw/day for infants under 1 year and 0.17 +/- 0.10 mu g/kg bw/day for infants between 1 and 3 years old. None of the estimates exceeded the FAO/WHO provisional maximum tolerable daily intake (PMTDI) of 10 mu g/kg bw/day.
英文关键词	Perchlorate food human milk MIREC
类型	Article
语种	英语
国家	Canada
收录类别	SCI-E
WOS记录号	WOS:000487975300001
WOS关键词	THYROID-FUNCTION ; INDOOR DUST ; HUMAN URINE ; EXPOSURE ; IODIDE ; WATER ; THIOCYANATE ; PREGNANCY ; DAIRY ; ASSOCIATION
WOS类目	Chemistry, Applied ; Food Science & Technology ; Toxicology
WOS研究方向	Chemistry ; Food Science & Technology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215653
作者单位	1.Hlth Canada, Hlth Prod & Food Branch, Bur Chem Safety Food Directorate, Ottawa, ON, Canada; 2.Hlth Canada, Food Directorate Hlth Prod & Food Branch, Bur Food Surveillance & Sci Integrat, Ottawa, ON, Canada; 3.Hlth Canada, Environm Hlth Sci & Res Bur, Hlth Environm & Consumer Safety Branch, Populat Studies Div, Ottawa, ON, Canada; 4.CHU Sherbrooke, Ctr Rech, Dept Obstet & Gynecol, Sherbrooke, PQ, Canada; 5.Univ Montreal, St Justine Univ Hosp, Res Ctr, Montreal, PQ, Canada
推荐引用方式 GB/T 7714	Wang, Zhongwen,Sparling, Melissa,Wang, Kuan Chiao,et al. Perchlorate in human milk samples from the maternal-infant research on environmental chemicals study (MIREC)[J],2019,36(12):1837-1846.
APA	Wang, Zhongwen,Sparling, Melissa,Wang, Kuan Chiao,Arbuckle, Tye E.,&Fraser, William.(2019).Perchlorate in human milk samples from the maternal-infant research on environmental chemicals study (MIREC).FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT,36(12),1837-1846.
MLA	Wang, Zhongwen,et al."Perchlorate in human milk samples from the maternal-infant research on environmental chemicals study (MIREC)".FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT 36.12(2019):1837-1846.