干旱区生态环境知识资源中心(Arid): Phoenix dactylifera L. seeds: a by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties

Arid

DOI	10.1039/c9fo01125k
	Phoenix dactylifera L. seeds: a by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties
	Djaoudene, Ouarda 1; Lopez, Victor 2,3; Casedas, Guillermo 2; Les, Francisco 2,3; Schisano, Connie 4; Bey, Mostapha Bachir 1; Tenore, Gian Carlo 4
通讯作者	Lopez, Victor
来源期刊	FOOD & FUNCTION
ISSN	2042-6496
EISSN	2042-650X
出版年	2019
卷号	10 期号:8 页码:4953-4965
英文摘要	Date (Phoenix dactylifera L.) seeds are a valuable and abundant by-product with various potential food applications and a source of functional and bioactive ingredients. In this study, date seeds from eight cultivars (Ourous OUR, Tazizaout TAZ, Tazarzeit TAR, Tazoughart TAG, Ouaouchet OUC, Oukasaba OUK, Delat DEL and Tamezwertn'telet TWT) cultivated in the M'zab oasis (south of Algeria) were analyzed for their chemical and phytochemical compositions, antioxidant capacities and in vitro inhibition of some enzymes. Variations in chemical compositions were observed in the studied date seeds. The greatest contents of total phenolic compounds (476 mg GAE per g dw), total flavonoids (6.52 mg QE per g dw), anthocyanins (1.26 mg Q3GE per g dw), flavonols (3.36 mg Q3GE per g dw), proanthocyanidins (85.13 mg CE per g dw), and ascorbic acid were detected in the seeds of the TAG cultivar. All extracts manifested good antioxidant activities tested by ORAC and FRAP assays. The OUC and OUR extracts displayed the most potent antioxidant capacity against DPPH free radicals (IC50 = 37.30 mu g ml(-1)) and ABTS(+) cation radicals (IC50 = 13.89 mu g ml(-1)), respectively. The antioxidant activity evaluated through a xanthine/xanthine oxidase system demonstrated that the TAZ extract was more efficient as a superoxide radical scavenger (IC50 = 9.08 mu g ml(-1)). Date seed extracts (DSE) exhibited inhibitory activities on enzymes, showing substantial potential as skin-whitening, neuroprotective, anti-hyperglycemic or anti-hyperlipidemic agents; the inhibitory potential was tested using tyrosinase (TYR), acetylcholinesterase (AChE), alpha-glucosidase (alpha-GLU) and lipase. All date seed cultivars were able to inhibit tyrosinase and alpha-glucosidase in a dose-dependent manner reaching the maximum inhibition.
类型	Article
语种	英语
国家	Algeria ; Spain ; Italy
开放获取类型	Green Published
收录类别	SCI-E
WOS记录号	WOS:000481481700041
WOS关键词	ALPHA-GLUCOSIDASE INHIBITORS ; ASCORBIC-ACID ; DATE SEEDS ; IN-VIVO ; FRUIT ; EXTRACT ; CHROMATOGRAPHY ; PHARMACOLOGY ; ANTHOCYANIN ; PHENOLICS
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215652
作者单位	1.Univ Bejaia, Fac Sci Nat & Vie, Lab Biochim Appl, Bejaia 06000, Algeria; 2.Univ San Jorge, Fac Hlth Sci, Dept Pharm, Zaragoza 50830, Spain; 3.Univ Zaragoza, CITA, IA2, E-50013 Zaragoza, Spain; 4.Univ Federico II, Dept Pharm, I-80131 Naples, Italy
推荐引用方式 GB/T 7714	Djaoudene, Ouarda,Lopez, Victor,Casedas, Guillermo,et al. Phoenix dactylifera L. seeds: a by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties[J],2019,10(8):4953-4965.
APA	Djaoudene, Ouarda.,Lopez, Victor.,Casedas, Guillermo.,Les, Francisco.,Schisano, Connie.,...&Tenore, Gian Carlo.(2019).Phoenix dactylifera L. seeds: a by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties.FOOD & FUNCTION,10(8),4953-4965.
MLA	Djaoudene, Ouarda,et al."Phoenix dactylifera L. seeds: a by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties".FOOD & FUNCTION 10.8(2019):4953-4965.