干旱区生态环境知识资源中心(Arid): The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring

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DOI	10.1017/S0950268818002613
	The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring
	Aiello, C. M.1,2; Esque, T. C.1; Nussear, K. E.3; Emblidge, P. G.2; Hudson, P. J.2
通讯作者	Aiello, C. M.
来源期刊	EPIDEMIOLOGY AND INFECTION
ISSN	0950-2688
EISSN	1469-4409
出版年	2019
卷号	147
英文摘要	The epidemiology of infectious diseases depends on many characteristics of disease progression, as well as the consistency of these processes across hosts. Longitudinal studies of infection can thus inform disease monitoring and management, but can be challenging in wildlife, particularly for long-lived hosts and persistent infections. Numerous tortoise species of conservation concern can be infected by pathogenic mycoplasmas that cause a chronic upper respiratory tract disease (URTD). Yet, a lack of detailed data describing tortoise responses to mycoplasma infections obscures our understanding of URTDs role in host ecology. We therefore monitored Mycoplasma agassizii infections in 14 captive desert tortoises and characterised clinical signs of disease, infection intensity, pathogen shedding and antibody production for nearly 4 years after initial exposure to donor hosts. Persistent infections established in all exposed tortoises within 10 weeks, but hosts appeared to vary in resistance, which affected the patterns of pathogen shedding and apparent disease. Delays in host immune response and changes to clinical signs and infection intensity over time resulted in inconsistencies between diagnostic tools and changes in diagnostic accuracy throughout the study. We discuss the implications these results have for URTD epidemiology and past and future research assessing disease prevalence and dynamics in tortoise populations.
英文关键词	Chronic infection Gopherus agassizii host resistance infectiousness reptile pathogens
类型	Article
语种	英语
国家	USA
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000455339100012
WOS关键词	RESPIRATORY-TRACT DISEASE ; DESERT TORTOISES ; GOPHERUS-AGASSIZII ; PREVALENCE ; STRATEGIES ; MOVEMENT ; PATTERNS ; EXPOSURE ; IMMUNITY ; ECOLOGY
WOS类目	Public, Environmental & Occupational Health ; Infectious Diseases
WOS研究方向	Public, Environmental & Occupational Health ; Infectious Diseases
来源机构	United States Geological Survey
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215558
作者单位	1.US Geol Survey, Western Ecol Res Ctr, Las Vegas Field Stn, Henderson, NV 89074 USA; 2.Penn State Univ, Ctr Infect Dis Dynam, Dept Biol, University Pk, PA 16802 USA; 3.Univ Nevada, Dept Geog, Reno, NV 89557 USA
推荐引用方式 GB/T 7714	Aiello, C. M.,Esque, T. C.,Nussear, K. E.,et al. The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring[J]. United States Geological Survey,2019,147.
APA	Aiello, C. M.,Esque, T. C.,Nussear, K. E.,Emblidge, P. G.,&Hudson, P. J..(2019).The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring.EPIDEMIOLOGY AND INFECTION,147.
MLA	Aiello, C. M.,et al."The slow dynamics of mycoplasma infections in a tortoise host reveal heterogeneity pertinent to pathogen transmission and monitoring".EPIDEMIOLOGY AND INFECTION 147(2019).