干旱区生态环境知识资源中心(Arid): Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification

Arid

DOI	10.1002/etc.4531
	Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification
	Kienzler, Aude 1; Connors, Kristin A.2; Bonnell, Mark 3; Barron, Mace G.4; Beasley, Amy 5; Inglis, Cristina G.3; Norberg-King, Teresa J.6; Martin, Todd 7; Sanderson, Hans 8; Vallotton, Nathalie 9; Wilson, Peter 10; Embry, Michelle R.11
通讯作者	Embry, Michelle R.
来源期刊	ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
ISSN	0730-7268
EISSN	1552-8618
出版年	2019
卷号	38 期号:10 页码:2294-2304
英文摘要	Multiple mode of action (MOA) frameworks have been developed in aquatic ecotoxicology, mainly based on fish toxicity. These frameworks provide information on a key determinant of chemical toxicity, but the MOA categories and level of specificity remain unique to each of the classification schemes. The present study aimed to develop a consensus MOA assignment within EnviroTox, a curated in vivo aquatic toxicity database, based on the following MOA classification schemes: Verhaar (modified) framework, Assessment Tool for Evaluating Risk, Toxicity Estimation Software Tool, and OASIS. The MOA classifications from each scheme were first collapsed into one of 3 categories: non-specifically acting (i.e., narcosis), specifically acting, or nonclassifiable. Consensus rules were developed based on the degree of concordance among the 4 individual MOA classifications to attribute a consensus MOA to each chemical. A confidence rank was also assigned to the consensus MOA classification based on the degree of consensus. Overall, 40% of the chemicals were classified as narcotics, 17% as specifically acting, and 43% as unclassified. Sixty percent of chemicals had a medium to high consensus MOA assignment. When compared to empirical acute toxicity data, the general trend of specifically acting chemicals being more toxic is clearly observed for both fish and invertebrates but not for algae. EnviroTox is the first approach to establishing a high-level consensus across 4 computationally and structurally distinct MOA classification schemes. This consensus MOA classification provides both a transparent understanding of the variation between MOA classification schemes and an added certainty of the MOA assignment. In terms of regulatory relevance, a reliable understanding of MOA can provide information that can be useful for the prioritization (ranking) and risk assessment of chemicals. Environ Toxicol Chem 2019;00:1-11. (c) 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
英文关键词	Mode of action aquatic toxicity classifications EnviroTox database ecological risk assessment
类型	Article
语种	英语
国家	Italy ; USA ; Canada ; Denmark ; Switzerland
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000485820900001
WOS关键词	ACUTE AQUATIC TOXICITY ; CHEMICALS ; PREDICTION
WOS类目	Environmental Sciences ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215556
作者单位	1.European Commiss, Joint Res Ctr, Ispra, Italy; 2.Procter & Gamble Co, Cincinnati, OH USA; 3.Environm & Climate Change Canada, Gatineau, PQ, Canada; 4.US EPA, Gulf Ecol Div, Gulf Breeze, FL USA; 5.Dow Chem Co USA, Midland, MI 48674 USA; 6.US EPA, Duluth, MN USA; 7.US EPA, Cinncinati, OH USA; 8.Aarhus Univ, Aarhus, Denmark; 9.Dow Chem Co USA, Basel, Switzerland; 10.Sanofi, Bridgewater, MA USA; 11.Hlth & Environm Sci Inst, Washington, DC 20005 USA
推荐引用方式 GB/T 7714	Kienzler, Aude,Connors, Kristin A.,Bonnell, Mark,et al. Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification[J],2019,38(10):2294-2304.
APA	Kienzler, Aude.,Connors, Kristin A..,Bonnell, Mark.,Barron, Mace G..,Beasley, Amy.,...&Embry, Michelle R..(2019).Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,38(10),2294-2304.
MLA	Kienzler, Aude,et al."Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 38.10(2019):2294-2304.