干旱区生态环境知识资源中心(Arid): Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Arid

DOI	10.1016/j.devcel.2019.07.023
	Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation
	Yamanaka, Soichiro 1,6; Nishihara, Hidenori 2; Toh, Hidehiro 3; Nagai, Luis Augusto Eijy 4; Hashimoto, Kosuke 5; Park, Sung-Joon 4; Shibuya, Aoi 1; Suzuki, Ana Maria 5; Tanaka, Yujiro 1; Nakai, Kenta 4; Carninci, Piero 5; Sasaki, Hiroyuki 3; Siomi, Haruhiko 1
通讯作者	Siomi, Haruhiko
来源期刊	DEVELOPMENTAL CELL
ISSN	1534-5807
EISSN	1878-1551
出版年	2019
卷号	51 期号:1 页码:21-+
英文摘要	Facultative heterochromatin forms and reorganizes in response to external stimuli. However, how the initial establishment of such a chromatin state is regulated in cell-cycle-arrested cells remains unexplored. Mouse gonocytes are arrested male germ cells, at which stage the genome-wide DNA methyl-ome forms. Here, we discovered transiently accessible heterochromatin domains of several mega-bases in size in gonocytes and named them differentially accessible domains (DADs). Open DADs formed in gene desert and gene cluster regions, primarily at transposons, with the reprogramming of histone marks, suggesting DADs as facultative heterochromatin. De novo DNA methylation took place with two waves in gonocytes: the first region specific and the second genome-wide. DADs were resistant to the first wave and their opening preceded the second wave. In addition, the higher-order chromosome architecture was reorganized with less defined chromosome compartments in gonocytes. These findings suggest that multiple layers of chromatin reprogramming facilitate de novo DNA methylation.
类型	Article
语种	英语
国家	Japan
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000489167900005
WOS关键词	READ ALIGNMENT ; GERM-CELLS ; SRA DOMAIN ; HISTONE H3 ; GENE ; CHROMATIN ; GENOME ; EXPRESSION ; DYNAMICS ; UHRF1
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215048
作者单位	1.Keio Univ, Dept Mol Biol, Sch Med, Tokyo 1608582, Japan; 2.Tokyo Inst Technol, Dept Life Sci & Technol, Yokohama, Kanagawa 2268501, Japan; 3.Kyushu Univ, Med Inst Bioregulat, Div Epigen & Dev, Fukuoka, Fukuoka 8128582, Japan; 4.Univ Tokyo, Human Genome Ctr, Inst Med Sci, Tokyo 1088639, Japan; 5.RIKEN, Ctr Life Sci Technol, Div Genom Technol, Yokohama Campus, Yokohama, Kanagawa 2300045, Japan; 6.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130032, Japan
推荐引用方式 GB/T 7714	Yamanaka, Soichiro,Nishihara, Hidenori,Toh, Hidehiro,et al. Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation[J],2019,51(1):21-+.
APA	Yamanaka, Soichiro.,Nishihara, Hidenori.,Toh, Hidehiro.,Nagai, Luis Augusto Eijy.,Hashimoto, Kosuke.,...&Siomi, Haruhiko.(2019).Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation.DEVELOPMENTAL CELL,51(1),21-+.
MLA	Yamanaka, Soichiro,et al."Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation".DEVELOPMENTAL CELL 51.1(2019):21-+.