干旱区生态环境知识资源中心(Arid): Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi

Arid

DOI	10.1016/j.crvi.2019.07.004
	Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi
	Tamegart, Lahcen 1; Abbaoui, Abdellatif 1; El Khiat, Abdelaati 1; Mustapha Bouyatas, Moulay 1,2; Gamrani, Halima 1
通讯作者	Gamrani, Halima
来源期刊	COMPTES RENDUS BIOLOGIES
ISSN	1631-0691
EISSN	1768-3238
出版年	2019
卷号	342 期号:5-6 页码:192-198
英文摘要	Exposure to lead is a threat factor for neurodegenerative disorders progress as it could trigger dopaminergic deficiency. We aimed herein to assess the effect of acute lead exposure (25 mg/kg B.W i.p.) during three continuous days on the dopaminergic and noradrenergic systems together with locomotor performance in Meriones shawi (M. shawi), then the neuroprotective potential of curcumin-III (30 mg/kg B.W) by oral gavage. Pb-exposed M. shawi exhibited increased tyrosine hydroxylase (TH) immunoreactivity in substantia nigra compacta (SNc), ventral tegmental area (VTA), locus coeruleus (LC), and dorsal striatum (DS), unlike the controls. This was correlated with decreased locomotor performance. A noticeable protective effect by co-treatment with curcumin-III was observed; in consequence, TH-immunoreactivity and locomotor disturbance were restored in Pb-treated Meriones. Our data results proved, on the one hand, an evident neurotoxic effect of acute Pb exposure and, on the other hand, a potent therapeutic effect of curcumin-III. Thereby, this compound may be recommended as a neuroprotective molecule for neurodegenerative disorders involving catecholaminergic impairment initiated by metallic elements. (C) 2019 Published by Elsevier Masson SAS on behalf of Academie des sciences.
英文关键词	Curcumin-III Lead neurotoxicity Midbrain Dopamine and noradrenaline Locomotion Meriones shawi
类型	Article
语种	英语
国家	Morocco
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000487588600008
WOS关键词	NUCLEUS-ACCUMBENS ; MONOAMINE-OXIDASE ; PARKINSONS-DISEASE ; AMINERGIC SYSTEM ; TIME-COURSE ; RAT-BRAIN ; EXPOSURE ; BEHAVIOR ; COPPER ; DEMETHOXYCURCUMIN
WOS类目	Biology
WOS研究方向	Life Sciences & Biomedicine - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214955
作者单位	1.Cadi Ayyad Univ, Fac Sci Semlalia, Neurosci Pharmacol & Environm Unit, Ave My Abdellah,BP 2390, Marrakech, Morocco; 2.Cadi Ayyad Univ, Multidisciplinary Fac Safi, Dept Biol, Safi, Morocco
推荐引用方式 GB/T 7714	Tamegart, Lahcen,Abbaoui, Abdellatif,El Khiat, Abdelaati,et al. Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi[J],2019,342(5-6):192-198.
APA	Tamegart, Lahcen,Abbaoui, Abdellatif,El Khiat, Abdelaati,Mustapha Bouyatas, Moulay,&Gamrani, Halima.(2019).Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi.COMPTES RENDUS BIOLOGIES,342(5-6),192-198.
MLA	Tamegart, Lahcen,et al."Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi".COMPTES RENDUS BIOLOGIES 342.5-6(2019):192-198.