干旱区生态环境知识资源中心(Arid): Development and application of the analytical method for illicit drugs and metabolites in fish tissues

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DOI	10.1016/j.chemosphere.2019.06.018
	Development and application of the analytical method for illicit drugs and metabolites in fish tissues
	Yin, Xingxing 1,2; Guo, Changsheng 1; Teng, Yanguo 2; Xu, Jian 1,2
通讯作者	Xu, Jian
来源期刊	CHEMOSPHERE
ISSN	0045-6535
EISSN	1879-1298
出版年	2019
卷号	233 页码:532-541
英文摘要	In this study, we developed a screening method for highly accurate and sensitive analysis of 12 illicit drugs and metabolites in fish tissues. The approach was based on ultrasonic-assisted extraction and solid phase extraction, followed by ultra-performance liquid chromatography-tandem mass spectrometry analysis. The homogenized samples were ultrasonic-assisted extracted with 1% acetic acid in methanol followed by SPE cleanup with Oasis MCX cartridge. The method was validated in accordance with the European Medicines Agency guidelines by evaluating the following required parameters: the limits of detection and limits of quantification, linearity, accuracy, repeatability, recovery of extraction, and matrix effect. For the tissues involved in this study, the recoveries ranged from 60% to 127%, and the matrix effect ranged from -19% to 83% with the inter- and intra-day variability below 12%. The method has been successfully applied to wild fish caught from six sampling sites of four urban rivers in Beijing, China. The analysis showed that the target compounds, including amphetamine, 3,4-methylenedioxyamphetamine, codeine and heroin were detected with high detection frequencies. Codeine exhibited the highest bioaccumulation factor (up to 73,986) in the muscle of Crucian carp, while ketamine tended to accumulate in the skin, 3,4-methylenedioxyamphetamine and heroin tended to accumulate in gastrointestinal tract, respectively. (C) 2019 Elsevier Ltd. All rights reserved.
英文关键词	Psychoactive substances Aquatic organisms Ultrasonic-assisted extraction Bioaccumulation Ultra-performance liquid chromatography-tandem mass spectrometry
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000477691500060
WOS关键词	PERSONAL CARE PRODUCTS ; WASTE-WATER ANALYSIS ; EMERGING CONTAMINANTS ; AQUATIC ENVIRONMENT ; SURFACE-WATER ; PHARMACEUTICALS ; BIOACCUMULATION ; KETAMINE ; ABUSE ; AMPHETAMINE
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
来源机构	北京师范大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214882
作者单位	1.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China; 2.Beijing Normal Univ, Coll Water Sci, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Yin, Xingxing,Guo, Changsheng,Teng, Yanguo,et al. Development and application of the analytical method for illicit drugs and metabolites in fish tissues[J]. 北京师范大学,2019,233:532-541.
APA	Yin, Xingxing,Guo, Changsheng,Teng, Yanguo,&Xu, Jian.(2019).Development and application of the analytical method for illicit drugs and metabolites in fish tissues.CHEMOSPHERE,233,532-541.
MLA	Yin, Xingxing,et al."Development and application of the analytical method for illicit drugs and metabolites in fish tissues".CHEMOSPHERE 233(2019):532-541.