干旱区生态环境知识资源中心(Arid): CD8+and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer

Arid

DOI	10.3390/cancers11091398
	CD8+and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer
	Echarti, Alessia 1; Hecht, Markus 1; Buettner-Herold, Maike 2; Haderlein, Marlen 1; Hartmann, Arndt 3; Fietkau, Rainer 1; Distel, Luitpold 1
通讯作者	Distel, Luitpold
来源期刊	CANCERS
EISSN	2072-6694
出版年	2019
卷号	11 期号:9
英文摘要	Background: The tumor immune status inflamed, immune excluded, and desert might serve as a predictive parameter. We studied these three cancer immune phenotypes while using a simple immunohistochemical algorithm. Methods: Pre-treatment tissue samples of 280 patients with locally advanced HNSCC treated with radiochemotherapy were analyzed. A double staining of CD8+ cytotoxic T cells (CTL) and FoxP3+ (Treg) was performed and the cell density was evaluated in the intraepithelial and stromal compartment of the tumor. Results: The classification of tumors as immune desert when stromal CTL were <= 50 cells/mm(2), inflamed when intraepithelial CTL were > 500 cells/mm(2), and as excluded when neither of these definitions met these cut off values allowed the best discrimination regarding overall survival. These groups had median OS periods of 37, 61, and 85 months, respectively. In immune desert and immune excluded tumors high Treg tended to worsen OS, but in inflamed tumors high Treg clearly improved OS. Conclusions: We propose that, in locally advanced HNSCC, the tumor immune state inflamed, immune excluded, and immune desert can be defined by intraepithelial and stromal CTL. Tregs can further subdivide these groups. The opposing effects of Tregs in the different groups might be the reason for the inconsistency of Tregs prognostic values published earlier.
英文关键词	CD8+ regulatory T cells FoxP3+ head and neck squamous cell carcinoma immune dessert inflamed excluded
类型	Article
语种	英语
国家	Germany
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000489719000183
WOS关键词	PROGNOSTIC VALUE ; CARCINOMA ; EXPRESSION ; CD8(+) ; INFILTRATION ; LYMPHOCYTES ; TONSILLAR ; FOXP3
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214788
作者单位	1.Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Radiat Oncol, D-91054 Erlangen, Germany; 2.Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Inst Pathol, Dept Nephropathol, D-91054 Erlangen, Germany; 3.Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Inst Pathol, D-91054 Erlangen, Germany
推荐引用方式 GB/T 7714	Echarti, Alessia,Hecht, Markus,Buettner-Herold, Maike,et al. CD8+and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer[J],2019,11(9).
APA	Echarti, Alessia.,Hecht, Markus.,Buettner-Herold, Maike.,Haderlein, Marlen.,Hartmann, Arndt.,...&Distel, Luitpold.(2019).CD8+and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer.CANCERS,11(9).
MLA	Echarti, Alessia,et al."CD8+and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer".CANCERS 11.9(2019).