干旱区生态环境知识资源中心(Arid): Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

Arid

DOI	10.1016/j.ccell.2019.05.004
	Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors
	Dangaj, Denarda 1,2; Bruand, Marine 1,2; Grimm, Alizee J.1,2; Ronet, Catherine 1,2; Barras, David 1,2,3; Duttagupta, Priyanka A.4,5; Lanitis, Evripidis 1,2; Duraiswamy, Jaikumar 4,6; Tanyi, Janos L.4; Benencia, Fabian 7; Conejo-Garcia, Jose 8; Ramay, Hena R.3,9; Montone, Kathleen T.10; Powell, Daniel J., Jr.4; Gimotty, Phyllis A.11; Facciabene, Andrea 4; Jackson, Donald G.12; Weber, Jeffrey S.13; Rodig, Scott J.14,15; Hodi, Stephen F.15; Kandalaft, Lana E.1,2; Irving, Melita 1,2; Zhang, Lin 4; Foukas, Periklis 1,2,16; Rusakiewicz, Sylvie 1,2; Delorenzi, Mauro 1,2,3; Coukos, George 1,2
通讯作者	Coukos, George
来源期刊	CANCER CELL
ISSN	1535-6108
EISSN	1878-3686
出版年	2019
卷号	35 期号:6 页码:885-+
英文摘要	We investigated the role of chemokines in regulating T cell accumulation in solid tumors. CCL5 and CXCL9 overexpression was associated with CD8(+) T cell infiltration in solid tumors. T cell infiltration required tumor cell-derived CCL5 and was amplified by IFN-gamma-inducible, myeloid cell-secreted CXCL9. CCL5 and CXCL9 coexpression revealed immunoreactive tumors with prolonged survival and response to checkpoint blockade. Loss of CCL5 expression in human tumors was associated with epigenetic silencing through DNA methylation. Reduction of CCL5 expression caused tumor-infiltrating lymphocyte (TIL) desertification, whereas forced CCL5 expression prevented Cxc/9 expression and TILs loss, and attenuated tumor growth in mice through IFN-gamma. The cooperation between tumor-derived CCL5 and IFN-gamma-inducible CXCR3 ligands secreted by myeloid cells is key for orchestrating T cell infiltration in immunoreactive and immunoresponsive tumors.
类型	Article
语种	英语
国家	Switzerland ; USA ; Canada ; Greece
开放获取类型	Green Accepted, Bronze
收录类别	SCI-E
WOS记录号	WOS:000470851400008
WOS关键词	OVARIAN-CANCER ; PD-1 BLOCKADE ; EXPRESSION ; MELANOMA ; GENE ; SURVIVAL ; THERAPY ; IMMUNOTHERAPY ; INFILTRATION ; TRAFFICKING
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214782
作者单位	1.Univ Lausanne, Ludwig Inst Canc Res, CH-1066 Lausanne, Switzerland; 2.Univ Lausanne, Dept Oncol, CH-1066 Lausanne, Switzerland; 3.SIB Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland; 4.Univ Penn, Ovarian Canc Res Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA; 5.Univ Chicago, Knapp Ctr Biomed Discovery, Dept Hematol & Oncol, Chicago, IL 60637 USA; 6.US FDA, Div Cell & Gene Therapy, OTAT, CBER, Silver Spring, MD 20993 USA; 7.Ohio Univ, Russ Coll Engn & Technol, Athens, OH 45701 USA; 8.H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol & Gynecol Oncol, Tampa, FL 33612 USA; 9.Univ Calgary, Int Microbiome Ctr, Calgary, AB, Canada; 10.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; 11.Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA; 12.Bristol Myers Squibb, Princeton, NJ 08540 USA; 13.NYU, Laura & Isaac Perlmutter Canc Ctr, 522 First Ave,Room 1310 Smilow Bldg, New York, NY 10016 USA; 14.Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA; 15.Dana Farber Canc Inst, Ctr Immunooncol, Boston, MA 02215 USA; 16.Univ Athens, Attikon Univ Hosp, Dept Pathol 2, Athens 12464, Greece
推荐引用方式 GB/T 7714	Dangaj, Denarda,Bruand, Marine,Grimm, Alizee J.,et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors[J],2019,35(6):885-+.
APA	Dangaj, Denarda.,Bruand, Marine.,Grimm, Alizee J..,Ronet, Catherine.,Barras, David.,...&Coukos, George.(2019).Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.CANCER CELL,35(6),885-+.
MLA	Dangaj, Denarda,et al."Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors".CANCER CELL 35.6(2019):885-+.