干旱区生态环境知识资源中心(Arid): A multi-imaging modality study of bone density, bone structure and the muscle

Arid

DOI	10.1016/j.bone.2019.05.022
	A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease
	Leonard, Mary B.1,2; Wehrli, Felix W.3; Ziolkowski, Susan L.2; Billig, Erica 4; Long, Jin 2; Nickolas, Thomas L.5; Magland, Jeremy F.3; Nihtianova, Snejana 6; Zemel, Babette S.7; Herskovitz, Rita 7; Rajapakse, Chamith S.3,8
通讯作者	Leonard, Mary B.
来源期刊	BONE
ISSN	8756-3282
EISSN	1873-2763
出版年	2019
卷号	127 页码:271-279
英文摘要	End stage renal disease (ESRD) is associated with sarcopenia and skeletal fragility. The objectives of this cross-sectional study were to (1) characterize body composition, bone mineral density (BMD) and bone structure in hemodialysis patients compared with controls, (2) assess whether DXA areal BMD (aBMD) correlates with peripheral quantitative CT (pQCT) measures of volumetric BMD (vBMD), cortical dimensions and MRI measures of trabecular microarchitecture, and (3) determine the magnitude of bone deficits in ESRD after adjustment for muscle mass. Thirty ESRD participants, ages 25 to 64 years, were compared with 403 controls for DXA and pQCT outcomes and 104 controls for MRI outcomes; results were expressed as race- and sex-specific Z-scores relative to age. DXA appendicular lean mass index (ALMI kg/m(2)) and total hip, femoral neck, ultradistal and 1/3rd radius aBMD were significantly lower in ESRD, vs. controls (all p < 0.01). pQCT trabecular vBMD (p < 0.01), cortical vBMD (p < 0.001) and cortical thickness (due to a greater endosteal circumference, p < 0.02) and MRI measures of trabecular number, trabecular thicicness, and whole bone stiffness were lower (all p < 0.01) in ESRD, vs. controls. ALMI was positively associated with total hip, femoral neck, ultradistal radius and 1/3rd radius aBMD and with tibia cortical thickness (R = 0.46 to 0.64). Adjustment for ALMI significantly attenuated bone deficits at these sites: e.g. mean femoral neck aBMD was 0.79 SD lower in ESRD, compared with controls and this was attenuated to 0.33 with adjustment for ALMI. In multivariate models within the dialysis participants, pQCT trabecular vBMD and cortical area Z-scores were significant and independently (all p < 0.02) associated with DXA femoral neck, total hip, and ultradistal radius aBMD Z-scores. Cortical vBMD (p = 0.01) and cortical area (p < 0.001) Z-scores were significantly and independently associated with 1/3rd radius areal aBMD Z-scores (R-2 = 0.62). These data demonstrate that DXA aBMD captures deficits in trabecular arid cortical vBMD and cortical area. The strong associations with ALMI, as an index of skeletal muscle, highlight the importance of considering the role of sarcopenia in skeletal fragility in patients with ESRD.
英文关键词	Chronic kidney disease Sarcopenia Bone mineral density DXA Quantitative computed tomography MRI
类型	Article
语种	英语
国家	USA
收录类别	SCI-E
WOS记录号	WOS:000483449000032
WOS关键词	PATIENTS RECEIVING HEMODIALYSIS ; CHRONIC KIDNEY-DISEASE ; MINERAL DENSITY ; HIP FRACTURE ; CORTICAL BONE ; COMPUTATIONAL BIOMECHANICS ; MECHANICAL STIMULATION ; COMPUTED-TOMOGRAPHY ; BODY-COMPOSITION ; TEMPORAL TRENDS
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214719
作者单位	1.Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA; 3.Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA; 4.Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA; 5.Columbia Univ, Dept Med, New York, NY USA; 6.Rice Univ, Susanne M Glasscock Sch Continuing Studies, Houston, TX USA; 7.Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA; 8.Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA
推荐引用方式 GB/T 7714	Leonard, Mary B.,Wehrli, Felix W.,Ziolkowski, Susan L.,et al. A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease[J],2019,127:271-279.
APA	Leonard, Mary B..,Wehrli, Felix W..,Ziolkowski, Susan L..,Billig, Erica.,Long, Jin.,...&Rajapakse, Chamith S..(2019).A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease.BONE,127,271-279.
MLA	Leonard, Mary B.,et al."A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease".BONE 127(2019):271-279.