干旱区生态环境知识资源中心(Arid): Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel

Arid

DOI	10.1186/s12867-019-0129-8
	Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel
	Cao, Yu; Zhang, Dong; Zhou, Huanmin
通讯作者	Zhang, Dong ; Zhou, Huanmin
来源期刊	BMC MOLECULAR BIOLOGY
ISSN	1471-2199
出版年	2019
卷号	20
英文摘要	BackgroundCamels possess the characteristics of salt- and drought-resistances, due to the long-time adaption to the living environment in desert. The camel resistance research on transcriptome is rare and deficient, especially reabsorption in renal cortex. Non-coding RNAs are normally considered as the RNA molecules that are not translated into proteins, their current roles remain mostly in regulation of information flux from DNA to protein, further on normal life activities and diseases. In order to reveal the mysterious veil of the post-transcriptional regulation of ncRNAs in renal cortex for the first time as far as we know, we designed and carried out the experiment of salt stress and water-deprivation stress in camel.ResultsBy means of RNA-seq in renal cortex of Alxa Bactrian Camel (Camelus bactrianus), we identified certain significantly differential RNAs, including 4 novel lncRNAs, 11 miRNAs and 13 mRNAs under salt stress, 0 lncRNAs, 18 miRNAs and 14 mRNAs under water-deprivation stress. By data analysis, the response pathway of post-transcriptional regulation concerning salt and water-deprivation stresses was put forward, involving preventing sodium from entering the cell, purifying of water and compensating neutral amino acids by miR-193b, miR-542-5p interaction with SLC6A19 mRNA.ConclusionBased on the resistance-related lncRNAs, miRNAs, and mRNAs, we proposed the post-transcriptional regulation pathway to explain how camels respond to salt and water-deprivation stresses in the ncRNAs regulation level of renal cortex for the first time, thus hoping to provide a theoretical basis for therapy of disease that is similar to high blood pressure in humans.
英文关键词	Camelus bactrianus Renal cortex Salt stress Water-deprivation stress Non-coding RNA Post-transcriptional regulation
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000464132100001
WOS关键词	RNA ; TRANSCRIPTS ; SODIUM
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214701
作者单位	Inner Mongolia Agr Univ, Coll Life Sci, 306 Zhaowuda Rd, Hohhot 010018, Peoples R China
推荐引用方式 GB/T 7714	Cao, Yu,Zhang, Dong,Zhou, Huanmin. Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel[J],2019,20.
APA	Cao, Yu,Zhang, Dong,&Zhou, Huanmin.(2019).Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel.BMC MOLECULAR BIOLOGY,20.
MLA	Cao, Yu,et al."Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel".BMC MOLECULAR BIOLOGY 20(2019).