干旱区生态环境知识资源中心(Arid): Genome-wide association study for response to vaccination in Angus calves(1)

Arid

DOI	10.1186/s12863-018-0709-5
	Genome-wide association study for response to vaccination in Angus calves(1)
	Kramer, L. M.1; Mayes, M. S.1; Downey, E. D.2; Tait, R. G.3; Woolums, A.4; Chase, C.5; Reecy, J. M.1
通讯作者	Reecy, J. M.
来源期刊	BMC GENETICS
ISSN	1471-2156
出版年	2019
卷号	20
英文摘要	BackgroundBovine respiratory disease complex (BRDC) is one of the most important sources of loss within the beef cattle industry in the USA. Steps have been taken to reduce the incidence of BRDC through vaccination. Despite the effectiveness of vaccines, large proportions of cattle still experience morbidity and mortality. Identification of genomic regions that are associated with variation in response to vaccination would allow for the selection of individuals genetically predisposed to respond to vaccination based on specific markers, while heritability and accuracy estimates would help facilitate genomic selection. This in turn may lead to selection for beef cattle herds that may have lower incidence rate of BRDC after vaccination. This study utilizes an Angus herd of more than 2000 head of cattle to identify these regions of association.ResultsGenome wide association studies were performed for viral neutralization antibody level and response to vaccination traits against four different viruses associated with BRDC: bovine viral diarrhea virus 1 and 2 (BVDV1 and BVDV2), bovine respiratory syncytial virus (BRSV), and bovine herpesvirus (BHV1). A total of six 1-Mb windows were associated with greater than 1% of the genetic variance for the analyzed vaccination response traits. Heritabilities ranged from 0.08 to 0.21 and prediction accuracy ranged from 0.01 to 0.33 across 7 different vaccination traits.ConclusionsAlthough six 1-Mb windows were identified as associated with 1% or greater genetic variance for viral neutralization antibody level and response to vaccination traits, few genes around these windows could readily be considered candidates. This indicates the need for further functional genomic annotation, as these regions appear to be gene deserts. Traits ranged from lowly to moderately heritable, which indicated the potential for selection of individuals that are genetically pre-disposed to respond to vaccination. The relatively low amount of genetic variance accounted for by any 1-Mb window indicated that viral neutralization antibody level and response to vaccination traits are polygenic in nature. Selection for these traits is possible, but likely to be slow due to the low heritabilities and absence of markers with high genetic variation associated with them.
英文关键词	Accuracy Beef cattle Bovine respiratory disease complex Genome-wide association study Heritability Immune response Vaccination
类型	Article
语种	英语
国家	USA
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000455208900001
WOS关键词	BOVINE RESPIRATORY-DISEASE ; VIRAL DIARRHEA VIRUS ; ANTIBODY-RESPONSE ; GENETIC-PARAMETERS ; IMMUNE-RESPONSE ; SYNCYTIAL VIRUS ; FEEDLOT CATTLE ; SYNDROME PRRS ; PERFORMANCE ; CARCASS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214690
作者单位	1.Iowa State Univ, Dept Anim Sci, 2255 Kildee Hall, Ames, IA 50011 USA; 2.Elanco Anim Hlth, Larchwood, IA 51241 USA; 3.Neogen GeneSeek Operat, Lincoln, NE 68504 USA; 4.Mississippi State Univ, Dept Pathobiol & Populat Med, Mississippi State, MS 39762 USA; 5.South Dakota State Univ, Dept Vet & Biomed Sci, Brookings, SD 57006 USA
推荐引用方式 GB/T 7714	Kramer, L. M.,Mayes, M. S.,Downey, E. D.,et al. Genome-wide association study for response to vaccination in Angus calves(1)[J],2019,20.
APA	Kramer, L. M..,Mayes, M. S..,Downey, E. D..,Tait, R. G..,Woolums, A..,...&Reecy, J. M..(2019).Genome-wide association study for response to vaccination in Angus calves(1).BMC GENETICS,20.
MLA	Kramer, L. M.,et al."Genome-wide association study for response to vaccination in Angus calves(1)".BMC GENETICS 20(2019).