干旱区生态环境知识资源中心(Arid): Resonance assignments for the tandem PWWP-ARID domains of human RBBP1

Arid

DOI	10.1007/s12104-019-09873-2
	Resonance assignments for the tandem PWWP-ARID domains of human RBBP1
	Gong, Weibin 1; Yao, Xingzhe 2,3,5; Liang, Qihui 1,5; Tong, Yufeng 4; Perrett, Sarah 1,5; Feng, Yingang 2,3
通讯作者	Perrett, Sarah ; Feng, Yingang
来源期刊	BIOMOLECULAR NMR ASSIGNMENTS
ISSN	1874-2718
EISSN	1874-270X
出版年	2019
卷号	13 期号:1 页码:177-181
英文摘要	Retinoblastoma-binding protein 1 (RBBP1), also known as AT-rich interaction domain 4A (ARID4A), is a tumour suppressor involved in the regulation of the epigenetic programming in leukemia and Prader-Willi/Angelman syndromes. The ARID domain of RBBP1 binds to DNA non-specifically and has gene suppression activity. However, no structural data has been obtained for the human RBBP1 ARID domain so far. Here we report the near-complete H-1, C-13, N-15 backbone and side-chain NMR assignment of a 27kDa tandem PWWP-ARID domain construct that spans residues 171-414 with the removal of a short disordered region between the two domains. The predicted secondary structure based on the assigned chemical shifts is consistent with the structures of the isolated PWWP domain of human RBBP1 previously solved and the homologous ARID domains of other proteins.
英文关键词	RBBP1 ARID domain Tandem domains NMR assignments Secondary structure
类型	Article
语种	英语
国家	Peoples R China ; Canada
收录类别	SCI-E
WOS记录号	WOS:000463649500034
WOS关键词	TRANSCRIPTIONAL REPRESSION ; RBP1 FAMILY ; IDENTIFICATION ; COMPLEX
WOS类目	Biophysics ; Spectroscopy
WOS研究方向	Biophysics ; Spectroscopy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214659
作者单位	1.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China; 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Shandong, Peoples R China; 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China; 4.Univ Windsor, Dept Chem & Biochem, Windsor, ON N9B 3P4, Canada; 5.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gong, Weibin,Yao, Xingzhe,Liang, Qihui,et al. Resonance assignments for the tandem PWWP-ARID domains of human RBBP1[J],2019,13(1):177-181.
APA	Gong, Weibin,Yao, Xingzhe,Liang, Qihui,Tong, Yufeng,Perrett, Sarah,&Feng, Yingang.(2019).Resonance assignments for the tandem PWWP-ARID domains of human RBBP1.BIOMOLECULAR NMR ASSIGNMENTS,13(1),177-181.
MLA	Gong, Weibin,et al."Resonance assignments for the tandem PWWP-ARID domains of human RBBP1".BIOMOLECULAR NMR ASSIGNMENTS 13.1(2019):177-181.