干旱区生态环境知识资源中心(Arid): Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation

Arid

DOI	10.1080/1354750X.2018.1514657
	Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation
	Dare, Theo O.1; Nicholls, Andrew W.2; Mantle, Peter G.3
通讯作者	Mantle, Peter G.
来源期刊	BIOMARKERS
ISSN	1354-750X
EISSN	1366-5804
出版年	2019
卷号	24 期号:2 页码:131-133
英文摘要	Context: Mupirocin (BactrobanA (R)) is widely prescribed for intra-nasal decolonisation of MRSA for in-patients awaiting surgery or self-medicated for out-patients although adherence for the latter is not monitored. Non-adherence is a widespread pharmaceutical problem but could encourage selection of antibiotic resistance. Mupirocin is only a topical antibiotic because it decomposes in stomach acidity to monic acid A, but this has not previously been exploited as a biomarker for clinical intra-nasal medication. Materials and methods: Urine from three catheterised patients in two London hospitals during and after mupirocin medication, was passed through Waters Oasis cartridges to isolate organic acids. Sensitive LC-MS-MS analysis for monic acid A in methanolic eluate has been developed to identify similar to 10 pg. Results: Monic acid A was quantified in all samples from one patient, translating into 6-46 ng from 12 mg mupirocin, assuming 1 L daily urine output. However, no urinary monic acid A was detected for two other patients. Discussion and conclusions: Consistent occurrence of monic acid A in urine of one mupirocin patient shows for the first time that antibiotic distribution across nasal mucous membranes had generally been maintained during medication. In contrast, consistent absence in the two other patients requires wider study in hospital.
英文关键词	Mupirocin Bactroban pseudomonic acid A biomarker monic acid A MRSA decolonisation antibiotic resistance LC-MS-MS
类型	Article
语种	英语
国家	England
收录类别	SCI-E
WOS记录号	WOS:000465158700005
WOS关键词	PSEUDOMONIC ACID
WOS类目	Biotechnology & Applied Microbiology ; Toxicology
WOS研究方向	Biotechnology & Applied Microbiology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214652
作者单位	1.GlaxoSmithKline R&D, Invest Safety & Drug Metab, Ware, Herts, England; 2.GlaxoSmithKline R&D, Bioimaging, Stevenage, Herts, England; 3.Imperial Coll London, Ctr Environm Policy, London SW7 1NE, England
推荐引用方式 GB/T 7714	Dare, Theo O.,Nicholls, Andrew W.,Mantle, Peter G.. Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation[J],2019,24(2):131-133.
APA	Dare, Theo O.,Nicholls, Andrew W.,&Mantle, Peter G..(2019).Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation.BIOMARKERS,24(2),131-133.
MLA	Dare, Theo O.,et al."Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation".BIOMARKERS 24.2(2019):131-133.