干旱区生态环境知识资源中心(Arid): Routine analytical method for monitoring the main metabolites for a recurrent group of parabens and pharmaceuticals in wastewater and tap water

Arid

DOI	10.1007/s00216-019-02035-2
	Routine analytical method for monitoring the main metabolites for a recurrent group of parabens and pharmaceuticals in wastewater and tap water
	Malvar, Jose Luis; Santos, Juan Luis; Martin, Julia; Aparicio, Irene; Alonso, Esteban
通讯作者	Santos, Juan Luis
来源期刊	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN	1618-2642
EISSN	1618-2650
出版年	2019
卷号	411 期号:25 页码:6625-6635
英文摘要	The presence of parabens and pharmaceuticals on the aquatic environment has been widely evaluated in the last years. Nevertheless, there is scarce information about the occurrence of their metabolites and/or degradation products in spite of the fact that they can be more toxic or more concentrated than their parent compounds. One of the main drawbacks for their monitoring is the lack of simple and reliable analytical methods for their routine determination. In this work, an analytical method has been developed and validated for the simultaneous extraction and determination of the main metabolites of the pharmaceuticals diclofenac, ibuprofen, sulfamethoxazole, carbamazepine and caffeine and of the parabens methylparaben and propylparaben and their parent compounds in wastewater and tap water samples. Sample extraction was carried out by conventional solid-phase extraction with OASIS HLB cartridges. Analytical determination was carried out by liquid chromatography-tandem mass spectrometry with electrospray ionization. Average accuracy was in the range from 66 to 120% in wastewater and from 86 to 120% in tap water. Precision, expressed as relative standard deviation, was lower than 17% for all the compounds. Method quantification limits were in the range from 1.0 to 33 ng L-1 in wastewater and from 0.5 to 28 ng L-1 in tap water. The method was applied to wastewater and tap water samples. None of the target compounds was detected in tap water whereas all of them were detected in wastewater. Concentrations of the metabolites were similar or higher than those of the parent compounds.
英文关键词	Metabolites Pharmaceuticals Personal care products Aqueous samples Solid-phase extraction Mass spectrometry
类型	Article
语种	英语
国家	Spain
收录类别	SCI-E
WOS记录号	WOS:000486030400013
WOS关键词	TRANSFORMATION PRODUCTS ; TREATMENT PLANTS ; CARBAMAZEPINE ; WASTEWATERS ; FATE ; MICROPOLLUTANTS ; EXTRACTION ; CAFFEINE ; EXPOSOME ; BEHAVIOR
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214146
作者单位	Univ Seville, Escuela Politecn Super, Dept Quim Analit, C Virgen Africa 7, Seville 41011, Spain
推荐引用方式 GB/T 7714	Malvar, Jose Luis,Santos, Juan Luis,Martin, Julia,et al. Routine analytical method for monitoring the main metabolites for a recurrent group of parabens and pharmaceuticals in wastewater and tap water[J],2019,411(25):6625-6635.
APA	Malvar, Jose Luis,Santos, Juan Luis,Martin, Julia,Aparicio, Irene,&Alonso, Esteban.(2019).Routine analytical method for monitoring the main metabolites for a recurrent group of parabens and pharmaceuticals in wastewater and tap water.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,411(25),6625-6635.
MLA	Malvar, Jose Luis,et al."Routine analytical method for monitoring the main metabolites for a recurrent group of parabens and pharmaceuticals in wastewater and tap water".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 411.25(2019):6625-6635.