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DOI	10.1007/s00216-019-01582-y
	Critical assessment of two sample treatment methods for multiresidue determination of veterinary drugs in milk by UHPLC-MS/MS
	Castilla-Fernandez, Delia 1; Moreno-Gonzalez, David 1; Beneito-Cambra, Miriam 1; Molina-Diaz, Antonio 1,2
通讯作者	Molina-Diaz, Antonio
来源期刊	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN	1618-2642
EISSN	1618-2650
出版年	2019
卷号	411 期号:7 页码:1433-1442
英文摘要	In this work, two sample treatment procedures have been evaluated for the determination of veterinary drug residues in milk. In order to cover a wide range of polarities, a total of 66 veterinary drugs with log K-ow ranging from -1 to 5 were selected. Two sample cleanup steps, (i) dispersive solid-phase extraction (dSPE) using enhanced matrix removal lipid as sorbent and (ii) solid-phase extraction (in pass-through mode) using Oasis HLB PRiME cartridges, were critically assessed in terms of sample throughput, recovery, matrix effect, cleanliness of extracts, limit of quantification, and repeatability. The veterinary drugs tested (viz. benzimidazoles, cephalosporins, imidazothiazoles, macrolides, NSAIDs, penicillins, quinolones, steroids, sulfonamides, and -agonists) were analyzed by ultra-high-performance liquid chromatography tandem mass spectrometry. According to the results, both methods exhibited similar recovery rates between 70 and 120% for most of compounds tested. Matrix effects were satisfactory for both methodologies, although the tolerance to matrix effects was slightly higher with HLB PRiME with nearly negligible matrix effects in most cases. Limits of quantitation were also well below the current maximum residue levels established by the European Union. Notably, sample throughput was higher in the case of HLB PRiME, since this pass-through SPE cleanup approach involved fewer steps than the EMR-Lipid dSPE approach. The results in terms of analysis time, sensitivity, precision, cleanliness of extracts, and matrix effect showed the suitability of both procedures for the monitoring of veterinary drugs residues in milk samples in a single run.
英文关键词	Sample treatment Veterinary drugs Milk HLB PRiME EMR-Lipid UHPLC-MS MS
类型	Article
语种	英语
国家	Spain
收录类别	SCI-E
WOS记录号	WOS:000463593300013
WOS关键词	MULTI-RESIDUE ANALYSIS ; MASS-SPECTROMETRY ; LC-MS/MS ; LIQUID ; VALIDATION ; QUANTIFICATION ; EXTRACTION ; PESTICIDES
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/214143
作者单位	1.Univ Jaen, Dept Phys & Analyt Chem, Analyt Chem Res Grp, Campus Las Lagunillas, Jaen 23071, Spain; 2.Ctr Adv Studies Olives Grove & Olive Oils CEAOAO, Sci & Technol Pk GEOLIT, Mengibar 23620, Spain
推荐引用方式 GB/T 7714	Castilla-Fernandez, Delia,Moreno-Gonzalez, David,Beneito-Cambra, Miriam,et al. Critical assessment of two sample treatment methods for multiresidue determination of veterinary drugs in milk by UHPLC-MS/MS[J],2019,411(7):1433-1442.
APA	Castilla-Fernandez, Delia,Moreno-Gonzalez, David,Beneito-Cambra, Miriam,&Molina-Diaz, Antonio.(2019).Critical assessment of two sample treatment methods for multiresidue determination of veterinary drugs in milk by UHPLC-MS/MS.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,411(7),1433-1442.
MLA	Castilla-Fernandez, Delia,et al."Critical assessment of two sample treatment methods for multiresidue determination of veterinary drugs in milk by UHPLC-MS/MS".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 411.7(2019):1433-1442.