干旱区生态环境知识资源中心(Arid): Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean

Arid

DOI	10.1016/j.actatropica.2018.11.019
	Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean
	Shiokawa, Kanae 1; Llanes, Alejandro 2; Hindoyan, Antreas 1; Cruz-Martinez, Luis 1; Welcome, Shamara 1; Rajeev, Sreekumari 1
通讯作者	Rajeev, Sreekumari
来源期刊	ACTA TROPICA
ISSN	0001-706X
EISSN	1873-6254
出版年	2019
卷号	190 页码:166-170
英文摘要	In this study, we investigated Leptospira infection and exposure in small Indian mongoose (Herpestes auropunctatus), an invasive animal species, in two different sites in the Caribbean island of Saint Kitts. Overall a low seroprevalence (12/148; 8.1%; 95%CI: 3.7-12.5) was observed. Agglutinating antibodies to serovars Mankarso (3.4%), Copenhageni (2.7%), Icterohemorrhagiae (1.4%), Bratislava (1.4%), Canicola (1.4%), Autumnalis (0.7%), Alexi (0.7%), Pomona (0.7%) and Grippotyphosa (0.7%) was observed on the microscopic agglutination test. The seroprevalence observed in mongooses trapped from peridomestic sites was significantly higher compared to the arid and less inhabited site (p = 0.0268). The real time PCR targeting lipL32 gene was positive for 9 out of 146 mongooses. Bacterial culture of kidneys resulted in two Leptospira isolates. Whole genome sequencing and analysis suggested that these isolates are closely related to L. interrogans serovar Copenhageni. We observed mild to severe chronic renal lesions in 20.2% of mongooses in the absence of an antibody response or active infection. Our findings emphasize the need to investigate other infectious etiologies or atypical outcomes and potential chronic long-term impact of Leptospira infection in animals and people living in an endemic area. In addition, our data reinforces the need for including locally prevalent Leptospira isolates rather than representative members of a serogroup in the microscopic agglutination test panel in epidemiologic and diagnostic investigations. In conclusion, mongoose inhabiting the island are exposed to and harbor pathogenic Leptospira and hence may play a role in the transmission. The invasive nature of the species highlights their presence as a potential risk factor for this widespread zoonotic disease.
英文关键词	Leptospira Mongoose Caribbean Zoonosis
类型	Article
语种	英语
国家	St Kitts & Nevi ; Panama
收录类别	SCI-E
WOS记录号	WOS:000457510400026
WOS关键词	HERPESTES-AUROPUNCTATUS ; PREVALENCE ; TRINIDAD ; SEROVARS ; GRENADA ; ISLAND
WOS类目	Parasitology ; Tropical Medicine
WOS研究方向	Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/213869
作者单位	1.Ross Univ, Sch Vet Med, POB 334, Basseterre, St Kitts & Nevi; 2.Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Ctr Biol Celular & Mol Enfermedades, Ciudad Del Saber, Panama
推荐引用方式 GB/T 7714	Shiokawa, Kanae,Llanes, Alejandro,Hindoyan, Antreas,et al. Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean[J],2019,190:166-170.
APA	Shiokawa, Kanae,Llanes, Alejandro,Hindoyan, Antreas,Cruz-Martinez, Luis,Welcome, Shamara,&Rajeev, Sreekumari.(2019).Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean.ACTA TROPICA,190,166-170.
MLA	Shiokawa, Kanae,et al."Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean".ACTA TROPICA 190(2019):166-170.