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This research aims at assessing land suitability for large-scale agriculture using multiple spatial datasets which include climate conditions, water potential, soil capabilities, topography and land management. The study case is in the Emirate of Abu Dhabi, in the UAE. The aridity of climate in the region requires accounting for non-renewable sources like desalination and treated sewage effluent (TSE) for an accurate and realistic assessment of irrigated agriculture suitability. All datasets were systematically aggregated using an analytical hierarchical process (AHP) in a GIS model. A hierarchal structure is built and pairwise comparisons matrices are used to calculate weights of the criteria. All spatial processes were integrated to model land suitability and different types of crops are considered in the analysis. Results show that jojoba and sorghum show the best capabilities to survive under the current conditions, followed by date palm, fruits and forage. Vegetables and cereals proved to be the least preferable options. Introducing desalinated water and TSE enhanced land suitability for irrigated agriculture. These findings have positive implications for national planning, the decision-making process of land alteration for agricultural use and addressing sustainable land management and food security issues.