Arid
DOI10.1016/j.schres.2017.06.015
Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment
Fusar-Poli, P.1,2; Palombini, E.1; Davies, C.1; Oliver, D.1; Bonoldi, I.1,2; Ramella-Cravaro, V.1; McGuire, P.3
通讯作者Fusar-Poli, P.
来源期刊SCHIZOPHRENIA RESEARCH
ISSN0920-9964
EISSN1573-2509
出版年2018
卷号192页码:385-390
英文摘要

Background: The reason for declining risk to psychosis across individuals assessed and meeting Ultra High Risk (UHR) criteria is still unclear. No studies have investigated the potential substantial role of the underlying risk enrichment across all the individuals undergoing an UHR assessment. Methods: Cohort study including all non-psychotic subjects who were assessed on suspicion of psychosis risk by the OASIS UHR service in the period 2001 to 2015. Posttest (after UHR assessment) and pretest risk (before UHR assessment) of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010. 2011-2015) with Cox analysis and modulating factors were investigated. Results: The posttest risk of psychosis at the OASIS service has increased from the initial pilot years of the service (2001-2005) and then stabilised and not declined over the following decade (2006-2010 and 2011-2015). This was paralleled by a similar course of pretest risk for psychosis. Stability of pretest risk for psychosis over the past decade was associated with a lack of change in ethnicity and to counter weighting changes in the type of referral sources over different time periods. Conclusions: The time course of transition risk to psychosis in UHR services is strictly associated with the time course of pretest risk enrichment. If the latter remains stable over time, as for the OASIS service, no declining transition risk is observed over the most recent years. Pretest risk enrichment is determined by recruitment and sampling strategies. This study confirms the need to control these factors in the UHR field. (C) 2017 Elsevier B.V. All rights reserved.


英文关键词Psychosis Schizophrenia Prevention Risk ARMS UHR
类型Article
语种英语
国家England
收录类别SCI-E ; SSCI
WOS记录号WOS:000426344800059
WOS关键词CLINICAL HIGH-RISK ; INDIVIDUALS ; DILUTION ; PREDICTION ; OUTREACH ; OUTCOMES ; PEOPLE ; WORK
WOS类目Psychiatry
WOS研究方向Psychiatry
来源机构University of London
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/212874
作者单位1.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England;
2.South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England;
3.Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England
推荐引用方式
GB/T 7714
Fusar-Poli, P.,Palombini, E.,Davies, C.,et al. Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment[J]. University of London,2018,192:385-390.
APA Fusar-Poli, P..,Palombini, E..,Davies, C..,Oliver, D..,Bonoldi, I..,...&McGuire, P..(2018).Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment.SCHIZOPHRENIA RESEARCH,192,385-390.
MLA Fusar-Poli, P.,et al."Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment".SCHIZOPHRENIA RESEARCH 192(2018):385-390.
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