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DOI | 10.1080/2162402X.2018.1450711 |
Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors | |
Soldevilla, Mario M.1,2; Villanueva, Helena1,2; Martinez-Velez, Naiara2,3,4; Meraviglia-Crivelli, Daniel1,2; Alonso, Marta M.2,3,4; Cebollero, Javier1,2; Menon, Ashwathi P.1,2; Puigdelloses, Montserrat2,3,4; Pastor, Fernando1,2 | |
通讯作者 | Pastor, Fernando |
来源期刊 | ONCOIMMUNOLOGY
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ISSN | 2162-402X |
出版年 | 2018 |
卷号 | 7期号:8 |
英文摘要 | In spite of the success of PD-1 blocking antibodies in the clinic their benefits are still restricted to a small fraction of patients. Immune-desert tumors and/or the highly immunosuppressive tumor milieu might hamper the success of PD-1/PD-L1 blocking therapies into a broader range of cancer patients. Although still under debate, there is a cumulative body of evidence that indicates B tumor-infiltrating lymphocytes are a good prognostic marker in most types of cancer, especially in those that form ectopic lymphoid tissue structures. Taking this into account, we reason that the adoptive transfer of activated B lymphoblasts (ABL) in the tumor could be a feasible therapeutic approach to shift the immunosuppressive tumor microenvironment into an immune-permissive one. In this work we show the antitumor effect of ABL therapy in two different tumor models: colon carcinoma (CT26) and melanoma (B16/F10). The ABL transfer in the most relevant non-immunogenic B16/F10 melanoma model depicts synergism with anti-PD-1 antibody therapy. Furthermore, systemic antitumor immunity was detected in mice treated with PD-1 antibody/ABL combination which was able to reach distal metastatic lesions. |
英文关键词 | cancer immunotherapy B lymphocytes PD1 |
类型 | Article |
语种 | 英语 |
国家 | Spain |
收录类别 | SCI-E |
WOS记录号 | WOS:000443907300006 |
WOS关键词 | TERTIARY LYMPHOID STRUCTURES ; CANCER-IMMUNOTHERAPY ; DENDRITIC CELLS ; FAVORABLE PROGNOSIS ; OVARIAN-CANCER ; LUNG-CANCER ; T-CELLS ; IN-VIVO ; LYMPHOCYTES ; INHIBITION |
WOS类目 | Oncology ; Immunology |
WOS研究方向 | Oncology ; Immunology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/211888 |
作者单位 | 1.Univ Navarra, Mol Therapeut Program, Ctr Appl Med Res, CIMA, Pamplona, Spain; 2.Recinto Complejo Hosp Navarra, Inst Invest Sanitaria Navarra IDISNA, Pamplona, Spain; 3.Fdn Appl Med Res, Program Solid Tumors & Biomarkers, Pamplona, Spain; 4.Univ Hosp Navarra, Dept Pediat, Pamplona, Spain |
推荐引用方式 GB/T 7714 | Soldevilla, Mario M.,Villanueva, Helena,Martinez-Velez, Naiara,et al. Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors[J],2018,7(8). |
APA | Soldevilla, Mario M..,Villanueva, Helena.,Martinez-Velez, Naiara.,Meraviglia-Crivelli, Daniel.,Alonso, Marta M..,...&Pastor, Fernando.(2018).Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors.ONCOIMMUNOLOGY,7(8). |
MLA | Soldevilla, Mario M.,et al."Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors".ONCOIMMUNOLOGY 7.8(2018). |
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