Arid
DOI10.1080/2162402X.2018.1450711
Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors
Soldevilla, Mario M.1,2; Villanueva, Helena1,2; Martinez-Velez, Naiara2,3,4; Meraviglia-Crivelli, Daniel1,2; Alonso, Marta M.2,3,4; Cebollero, Javier1,2; Menon, Ashwathi P.1,2; Puigdelloses, Montserrat2,3,4; Pastor, Fernando1,2
通讯作者Pastor, Fernando
来源期刊ONCOIMMUNOLOGY
ISSN2162-402X
出版年2018
卷号7期号:8
英文摘要

In spite of the success of PD-1 blocking antibodies in the clinic their benefits are still restricted to a small fraction of patients. Immune-desert tumors and/or the highly immunosuppressive tumor milieu might hamper the success of PD-1/PD-L1 blocking therapies into a broader range of cancer patients. Although still under debate, there is a cumulative body of evidence that indicates B tumor-infiltrating lymphocytes are a good prognostic marker in most types of cancer, especially in those that form ectopic lymphoid tissue structures. Taking this into account, we reason that the adoptive transfer of activated B lymphoblasts (ABL) in the tumor could be a feasible therapeutic approach to shift the immunosuppressive tumor microenvironment into an immune-permissive one. In this work we show the antitumor effect of ABL therapy in two different tumor models: colon carcinoma (CT26) and melanoma (B16/F10). The ABL transfer in the most relevant non-immunogenic B16/F10 melanoma model depicts synergism with anti-PD-1 antibody therapy. Furthermore, systemic antitumor immunity was detected in mice treated with PD-1 antibody/ABL combination which was able to reach distal metastatic lesions.


英文关键词cancer immunotherapy B lymphocytes PD1
类型Article
语种英语
国家Spain
收录类别SCI-E
WOS记录号WOS:000443907300006
WOS关键词TERTIARY LYMPHOID STRUCTURES ; CANCER-IMMUNOTHERAPY ; DENDRITIC CELLS ; FAVORABLE PROGNOSIS ; OVARIAN-CANCER ; LUNG-CANCER ; T-CELLS ; IN-VIVO ; LYMPHOCYTES ; INHIBITION
WOS类目Oncology ; Immunology
WOS研究方向Oncology ; Immunology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/211888
作者单位1.Univ Navarra, Mol Therapeut Program, Ctr Appl Med Res, CIMA, Pamplona, Spain;
2.Recinto Complejo Hosp Navarra, Inst Invest Sanitaria Navarra IDISNA, Pamplona, Spain;
3.Fdn Appl Med Res, Program Solid Tumors & Biomarkers, Pamplona, Spain;
4.Univ Hosp Navarra, Dept Pediat, Pamplona, Spain
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Soldevilla, Mario M.,Villanueva, Helena,Martinez-Velez, Naiara,et al. Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors[J],2018,7(8).
APA Soldevilla, Mario M..,Villanueva, Helena.,Martinez-Velez, Naiara.,Meraviglia-Crivelli, Daniel.,Alonso, Marta M..,...&Pastor, Fernando.(2018).Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors.ONCOIMMUNOLOGY,7(8).
MLA Soldevilla, Mario M.,et al."Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors".ONCOIMMUNOLOGY 7.8(2018).
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