Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1093/nar/gky797 |
Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions | |
Wu, Xia1,2; Kabalane, Hadi3; Kahli, Malik1,11; Petryk, Nataliya1,12; Laperrousaz, Bastien3,4; Jaszczyszyn, Yan5; Drillon, Guenola3; Nicolini, Frank-Emmanuel4,6; Perot, Gaelle7; Robert, Aude8; Fund, Cederic9; Chibon, Frederic7,13; Xia, Ruohong2; Wiels, Joelle8; Argoul, Francois10; Maguer-Satta, Veronique4; Arneodo, Alain10; Audit, Benjamin3; Hyrien, Olivier1 | |
通讯作者 | Audit, Benjamin ; Hyrien, Olivier |
来源期刊 | NUCLEIC ACIDS RESEARCH
![]() |
ISSN | 0305-1048 |
EISSN | 1362-4962 |
出版年 | 2018 |
卷号 | 46期号:19页码:10157-10172 |
英文摘要 | The spatiotemporal program of metazoan DNA replication is regulated during development and altered in cancers. We have generated novel OK-seq, Repliseq and RNA-seq data to compare the DNA replication and gene expression programs of twelve cancer and non-cancer human cell types. Changes in replication fork directionality (RFD) determined by OK-seq are widespread but more frequent within GC-poor isochores and largely disconnected from transcription changes. Cancer cell RFD profiles cluster with non-cancer cells of similar developmental origin but not with different cancer types. Importantly, recurrent RFD changes are detected in specific tumour progression pathways. Using a model for establishment and early progression of chronic myeloid leukemia (CML), we identify 1027 replication initiation zones (IZs) that progressively change efficiency during long-term expression of the BCR-ABL1 oncogene, being twice more often downregulated than upregulated. Prolonged expression of BCR-ABL1 results in targeting of new IZs and accentuation of previous efficiency changes. Targeted IZs are predominantly located in GC-poor, late replicating gene deserts and frequently silenced in late CML. Prolonged expression of BCR-ABL1 results in massive deletion of GC-poor, late replicating DNA sequences enriched in origin silencing events. We conclude that BCR-ABL1 expression progressively affects replication and stability of GC-poor, late-replicating regions during CML progression. |
类型 | Article |
语种 | 英语 |
国家 | France ; Peoples R China ; USA ; Denmark |
收录类别 | SCI-E |
WOS记录号 | WOS:000450955800026 |
WOS关键词 | CHRONIC MYELOGENOUS LEUKEMIA ; DAMAGE-RESPONSE ; DOMAINS ; STRESS ; LANDSCAPE ; REVEALS ; BARRIER ; MODEL ; GENE ; PART |
WOS类目 | Biochemistry & Molecular Biology |
WOS研究方向 | Biochemistry & Molecular Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/211859 |
作者单位 | 1.PSL Res Univ, CNRS, INSERM, Ecole Normale Super,Dept Biol,IBENS, F-75005 Paris, France; 2.East China Normal Univ, Phys Dept, Shanghai, Peoples R China; 3.Univ Claude Bernard Lyon 1, Univ Lyon, CNRS, Lab Phys,ENS Lyon, F-69342 Lyon, France; 4.Ctr Rech & Cancerol Lyon, CNRS, INSERM, UMR5286,U1052, F-69008 Lyon, France; 5.Univ Paris Saclay, Univ Paris Sud, CNRS, CEA,Inst Integrat Biol Cell I2BC, Gif Sur Yvette, France; 6.Ctr Leon Berard, F-69008 Lyon, France; 7.INSERM, U1218, Inst Bergonie, F-33000 Bordeaux, France; 8.Univ Paris Sud Paris Saclay, CNRS, Inst Gustave Roussy, UMR 8126, Villejuif, France; 9.PSL Res Univ, CNRS, INSERM, IBENS,Plateforme Genom,Ecole Normale Super, F-75005 Paris, France; 10.Univ Bordeaux, CNRS, LOMA, UMR 5798, F-33405 Talence, France; 11.NYU, Dept Biol, New York, NY 10003 USA; 12.Univ Copenhagen, BRIC, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark; 13.CRCT, INSERM, U1037, Inst Claudius Regaud, F-31037 Toulouse, France |
推荐引用方式 GB/T 7714 | Wu, Xia,Kabalane, Hadi,Kahli, Malik,et al. Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions[J],2018,46(19):10157-10172. |
APA | Wu, Xia.,Kabalane, Hadi.,Kahli, Malik.,Petryk, Nataliya.,Laperrousaz, Bastien.,...&Hyrien, Olivier.(2018).Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions.NUCLEIC ACIDS RESEARCH,46(19),10157-10172. |
MLA | Wu, Xia,et al."Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions".NUCLEIC ACIDS RESEARCH 46.19(2018):10157-10172. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。