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DOI | 10.1002/lary.26883 |
Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar | |
Pitman, Michael J.1; Kurita, Takashi2; Powell, Maria E.2; Kimball, Emily E.3; Mizuta, Masanobu4; Chang, Siyuan5; Garrett, C. Gaelyn2; Rousseau, Bernard2 | |
通讯作者 | Pitman, Michael J. |
来源期刊 | LARYNGOSCOPE
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ISSN | 0023-852X |
EISSN | 1531-4995 |
出版年 | 2018 |
卷号 | 128期号:4页码:901-908 |
英文摘要 | Objectives/HypothesisVocal fold scar is a major cause of dysphonia, and optimal treatments do not currently exist. Small intestinal submucosa (SIS) is a biomaterial developed for the treatment of a variety of pathologies. The purpose of this study was to investigate the effects of SIS implantation on tissue remodeling in scarred vocal folds using routine staining, immunohistochemistry, and high-speed videoendoscopy (HSV). Study DesignProspective, blinded group analysis. MethodsThirteen New Zealand White rabbits underwent a vocal fold scarring procedure followed by microflap elevation with or without SIS implantation. Seven months later, they underwent a phonation procedure with HSV and laryngeal harvest. Alcian blue and elastica van Gieson staining and immunohistochemistry for collagen types I and III were used to evaluate histological healing outcomes. Dynamic functional remodeling of the scarred vocal fold in the presence of SIS implants was evaluated using HSV imaging to capture restoration of vibratory amplitude, amplitude ratio, and left-right phase symmetry. ResultsDensity of collagen I was significantly decreased in SIS versus microflap-treated vocal folds. No differences were found between groups for hyaluronic acid, elastin, or collagen type III. Organization of elastin in the subepithelial region appeared to affect amplitude of vibration and the shape of the vocal fold edge. ConclusionsSIS implantation into chronic scar reduced the density of collagen I deposits. There was no evidence of a negative impact or complication from SIS implantation. Regardless of treatment type, organization of elastin in the subepithelial region may be important to vibratory outcomes. Level of EvidenceNA. Laryngoscope, 128:901-908, 2018 |
英文关键词 | Vocal fold scar small intestinal submucosa voice disorders wound healing histology high-speed videoendoscopy dysphonia tissue regeneration |
类型 | Article ; Proceedings Paper |
语种 | 英语 |
国家 | USA ; Japan |
收录类别 | SCI-E ; CPCI-S |
WOS记录号 | WOS:000428468400027 |
WOS关键词 | AUTOLOGOUS FAT IMPLANTATION ; FIBROBLAST-GROWTH-FACTOR ; OASIS WOUND MATRIX ; HYALURONIC-ACID ; HISTOLOGIC CHARACTERIZATION ; SULCUS ; INJECTION ; EFFICACY ; LAYER |
WOS类目 | Medicine, Research & Experimental ; Otorhinolaryngology |
WOS研究方向 | Research & Experimental Medicine ; Otorhinolaryngology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/211532 |
作者单位 | 1.Columbia Univ, Med Ctr, New York Presbyterian, Dept Otolaryngol Head & Neck Surg,Voice & Swallow, Harkness Pavil 8-863,180 Ft Washington Ave, New York, NY 10032 USA; 2.Vanderbilt Univ, Med Ctr, Dept Otolaryngol, Nashville, TN 37232 USA; 3.Vanderbilt Univ, Med Ctr, Dept Hearing & Speech Sci, Nashville, TN USA; 4.Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan; 5.Corning Res & Dev Corp, Painted Post, NY USA |
推荐引用方式 GB/T 7714 | Pitman, Michael J.,Kurita, Takashi,Powell, Maria E.,et al. Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar[J],2018,128(4):901-908. |
APA | Pitman, Michael J..,Kurita, Takashi.,Powell, Maria E..,Kimball, Emily E..,Mizuta, Masanobu.,...&Rousseau, Bernard.(2018).Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar.LARYNGOSCOPE,128(4),901-908. |
MLA | Pitman, Michael J.,et al."Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar".LARYNGOSCOPE 128.4(2018):901-908. |
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