Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1002/jssc.201701360 |
Simultaneous determination of 29 pharmaceuticals in fish muscle and plasma by ultrasonic extraction followed by SPE-UHPLC-MS/MS | |
Li, You-yu; Hu, Xia-lin; Bao, Yi-fan; Yin, Da-qiang | |
通讯作者 | Hu, Xia-lin |
来源期刊 | JOURNAL OF SEPARATION SCIENCE
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ISSN | 1615-9306 |
EISSN | 1615-9314 |
出版年 | 2018 |
卷号 | 41期号:10页码:2139-2150 |
英文摘要 | A confirmatory method for the simultaneous detection of 29 pharmaceuticals in fish muscle and plasma was developed by using solid-phase extraction combined with ultra-high performance liquid chromatography and tandem mass spectrometry. Fish samples were extracted with methanol and enriched using Oasis HLB solid-phase extraction columns in one step. Twenty-nine target pharmaceuticals were quantified by the internal standard method and the calibration curves showed good linearity in a wide range with determination coefficients of greater than 0.913. The detection limits of the pharmaceuticals ranged from 0.01 to 2.00 mu g/kg (mu g/L). The applicability of the method was checked by precision and recovery experiments. The average recoveries of the 29 pharmaceuticals were between 61 and 111%, and all the relative standard deviations were below 25%. Our reported method has been demonstrated to be sensitive, convenient, rapid, and reliable for the simultaneous determination of 29 pharmaceuticals in fish muscle and plasma. Real sample determination showed that 25 and 9 of the 29 compounds were detected in fish muscle and plasma, respectively. |
英文关键词 | fish pharmaceuticals plasma tandem mass spectrometry ultra performance liquid chromatography |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000434143400004 |
WOS关键词 | TANDEM MASS-SPECTROMETRY ; PERSONAL CARE PRODUCTS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ENVIRONMENTAL RISK-ASSESSMENT ; SOLID-PHASE EXTRACTION ; WATER TREATMENT PLANTS ; WASTE-WATER ; TISSUE DISTRIBUTION ; DRINKING-WATER ; FRESH-WATER |
WOS类目 | Chemistry, Analytical |
WOS研究方向 | Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/211285 |
作者单位 | Tongji Univ, Coll Environm Sci & Engn, Minist Educ, Key Lab Yangtze River Water Environm, 1239 Siping Rd, Shanghai 200092, Peoples R China |
推荐引用方式 GB/T 7714 | Li, You-yu,Hu, Xia-lin,Bao, Yi-fan,et al. Simultaneous determination of 29 pharmaceuticals in fish muscle and plasma by ultrasonic extraction followed by SPE-UHPLC-MS/MS[J],2018,41(10):2139-2150. |
APA | Li, You-yu,Hu, Xia-lin,Bao, Yi-fan,&Yin, Da-qiang.(2018).Simultaneous determination of 29 pharmaceuticals in fish muscle and plasma by ultrasonic extraction followed by SPE-UHPLC-MS/MS.JOURNAL OF SEPARATION SCIENCE,41(10),2139-2150. |
MLA | Li, You-yu,et al."Simultaneous determination of 29 pharmaceuticals in fish muscle and plasma by ultrasonic extraction followed by SPE-UHPLC-MS/MS".JOURNAL OF SEPARATION SCIENCE 41.10(2018):2139-2150. |
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