干旱区生态环境知识资源中心(Arid): Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

Arid

DOI	10.1021/acs.jnatprod.7b00992
	Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
	Kumar, Rohitesh; Duffy, Sandra; Avery, Vicky M.; Carroll, Anthony R.; Davis, Rohan A.
通讯作者	Davis, Rohan A.
来源期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
EISSN	1520-6025
出版年	2018
卷号	81 期号:4 页码:1079-1083
英文摘要	Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 mu M. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.
类型	Article
语种	英语
国家	Australia
收录类别	SCI-E
WOS记录号	WOS:000431165100045
WOS关键词	PSEUDOPTEROGORGIA-ELISABETHAE ; DITERPENOID ALKALOIDS ; BIOSYNTHESIS ; MYOPORACEAE ; DUTTONII
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/211195
作者单位	Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia
推荐引用方式 GB/T 7714	Kumar, Rohitesh,Duffy, Sandra,Avery, Vicky M.,et al. Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca[J],2018,81(4):1079-1083.
APA	Kumar, Rohitesh,Duffy, Sandra,Avery, Vicky M.,Carroll, Anthony R.,&Davis, Rohan A..(2018).Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca.JOURNAL OF NATURAL PRODUCTS,81(4),1079-1083.
MLA	Kumar, Rohitesh,et al."Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca".JOURNAL OF NATURAL PRODUCTS 81.4(2018):1079-1083.