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In arid, coastal cities, water demand is often met through large-scale desalination systems. However, the energy required to run desalination plants remains a drawback. Further, numerous low-density population areas lack not only fresh water availability, but in most of the cases electrical grid connection or any other energy source as well. The challenge, consequently, is to ensure adequate fresh water supplies at the lowest possible cost. The main objective of this work is to assess the freshwater production from a reverse osmosis desalination system powered by a wave energy converter, the Overtopping Breakwater for Wave Energy Conversion (OBREC). The desktop analysis is illustrated through a case study on the Fenoarivo Atsinanana coast, along north-eastern Madagascar. The novel aspect of the analysis method is the application of a specific numerical code calibrated using preliminary results from a two-year monitoring campaign of the first OBREC prototype in operation in Naples Harbour (Italy). Instead of dissipating the incoming wave energy, the system collects the overtopping water above the sea level and the potential energy is converted into electricity through low head turbines. Then, the flow will be driven towards the desalination system. This configuration seems like a promising opportunity for developing countries to meet their water supply needs while at the same time developing their renewable energy potential.