Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1155/2018/2834049 |
A Convenient and Sensitive LC-MS/MS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues | |
Zhang, Heying1; Qu, Wei1; Tao, Yanfei2,3; Chen, Dongmei2,3; Xie, Shuyu1; Huang, Lingli1,2,3; Liu, Zhenli1,2,3; Pan, Yuanhu1,2,3; Yuan, Zonghui1,2,3 | |
通讯作者 | Pan, Yuanhu |
来源期刊 | JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY |
ISSN | 2090-8865 |
EISSN | 2090-8873 |
出版年 | 2018 |
英文摘要 | This paper presents a convenient and sensitive LC-MS/MS method for the simultaneous determination of carbadox and olaquindox residues, including desoxyolaquindox (DOLQ), desoxycarbadox (DCBX), quinoxaline-2-carboxylic acid (QCA), 3-methyl-quinoxaline-2-carboxylic acid (MQCA), and the glycine conjugates of QCA and MQCA (namely, QCA-glycine and MQCA-glycine, resp.) in swine muscle and liver tissues. Tissue samples were extracted with 2% metaphosphoric acid in 20% methanol and cleaned up by solid-phase extraction (SPE) on a mixed-mode anion-exchange column (Oasis MAX). Analysis was performed on a C-18 column by detection with mass spectrometry in the multiple reaction monitoring (MRM) mode. The limits of detection (LODs) of the six analytes were determined to be 0.01 mu g.kg(-1) to 0.25 mu g.kg(-1), and the limits of quantification (LOQs) were 0.02 mu g.kg(-1) to 0.5 mu g.kg(-1). The total recoveries of the six analytes in all tissues were higher than 79.1% with the RSD% less than 9.2%. The developed method can determine the real residue level of QCA and MQCA, whether they are present in free form or as glycine conjugates in tissues, together with the carcinogenic desoxy metabolites DCBX and DOLQ with high recovery. Therefore, this method was suitable for routine analysis of residue control programmes and the residue depletion study of CBX and OLQ on swine. |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000436350800001 |
WOS关键词 | TANDEM MASS-SPECTROMETRY ; PORCINE LIVER ; QUINOXALINE-2-CARBOXYLIC ACID ; IN-VITRO ; METABOLITES ; CONFIRMATION ; ELECTROSPRAY ; VALIDATION ; CELLS |
WOS类目 | Chemistry, Analytical ; Engineering, Civil |
WOS研究方向 | Chemistry ; Engineering |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/210444 |
作者单位 | 1.Huazhong Agr Univ, MOA Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China; 2.Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China; 3.Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Heying,Qu, Wei,Tao, Yanfei,et al. A Convenient and Sensitive LC-MS/MS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues[J],2018. |
APA | Zhang, Heying.,Qu, Wei.,Tao, Yanfei.,Chen, Dongmei.,Xie, Shuyu.,...&Yuan, Zonghui.(2018).A Convenient and Sensitive LC-MS/MS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues.JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY. |
MLA | Zhang, Heying,et al."A Convenient and Sensitive LC-MS/MS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues".JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2018). |
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