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Widespread cannabis use is a concern in Israel, and its popularity continues to grow despite government and non-government prevention, education, and treatment efforts. The National Service for Treatment of Addiction (Service), Israel Ministry of Social Affairs and Social Services maintains a fundamental position that cannabis is an illegal, harmful, and addictive substance. The purpose of this paper is to provide an overview of cannabis use in the country and provide insight of the challenges being faced resulting from use of the substance. Particular attention is given to the Negev region of the country, Israel’s arid southern region that has been referred to as the country’s "barn for drugs." Concern is expressed about the investment of limited resources needed for cannabis problem management, outreach service, prevention, and treatment when there are other national priorities to address such as security, education, health care, and employment opportunities to address.