Arid
DOI10.1186/s13059-018-1393-5
The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages
D’Atanasio, Eugenia1,2; Trombetta, Beniamino1; Bonito, Maria1; Finocchio, Andrea3; Di Vito, Genny1; Seghizzi, Mara1; Romano, Rita4; Russo, Gianluca4; Paganotti, Giacomo Maria5,6; Watson, Elizabeth7; Coppa, Alfredo8; Anagnostou, Paolo8,9; Dugoujon, Jean-Michel10; Moral, Pedro11; Sellitto, Daniele12; Novelletto, Andrea3; Cruciani, Fulvio1,12
通讯作者Cruciani, Fulvio
来源期刊GENOME BIOLOGY
ISSN1474-760X
出版年2018
卷号19
英文摘要

Background: Little is known about the peopling of the Sahara during the Holocene climatic optimum, when the desert was replaced by a fertile environment.


Results: In order to investigate the role of the last Green Sahara in the peopling of Africa, we deep-sequence the whole non-repetitive portion of the Y chromosome in 104 males selected as representative of haplogroups which are currently found to the north and to the south of the Sahara. We identify 5,966 mutations, from which we extract 142 informative markers then genotyped in about 8,000 subjects from 145 African, Eurasian and African American populations. We find that the coalescence age of the trans-Saharan haplogroups dates back to the last Green Sahara, while most northern African or sub-Saharan clades expanded locally in the subsequent arid phase.


Conclusions: Our findings suggest that the Green Sahara promoted human movements and demographic expansions, possibly linked to the adoption of pastoralism. Comparing our results with previously reported genome-wide data, we also find evidence for a sex-biased sub-Saharan contribution to northern Africans, suggesting that historical events such as the trans-Saharan slave trade mainly contributed to the mtDNA and autosomal gene pool, whereas the northern African paternal gene pool was mainly shaped by more ancient events.


英文关键词MSY Target next generation sequencing Green Sahara Trans-Saharan haplogroups
类型Article
语种英语
国家Italy ; Botswana ; USA ; Sweden ; France ; Spain
收录类别SCI-E
WOS记录号WOS:000425109700001
WOS关键词HUMAN Y-CHROMOSOME ; HIGH-RESOLUTION ANALYSIS ; SEGMENTAL DUPLICATIONS ; GENETIC LANDSCAPE ; MIGRATORY EVENTS ; MTDNA VARIATION ; HAPLOGROUP-E ; AFRICA ; SEQUENCE ; EXPANSION
WOS类目Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/209530
作者单位1.Sapienza Univ Roma, Dipartimento Biol & Biotecnol C Darwin, Rome, Italy;
2.Sapienza Univ Roma, Fdn Cenci Bolognetti, Ist Pasteur, Rome, Italy;
3.Univ Roma Tor Vergata, Dipartimento Biol, Rome, Italy;
4.Sapienza Univ Roma, Dipartimento Sanita Pubbl & Malattie Infett, Rome, Italy;
5.Botswana Univ Pennsylvania Partnership, Gaborone, Botswana;
6.Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA;
7.Swedish Museum Nat Hist, Stockholm, Sweden;
8.Sapienza Univ Roma, Dipartimento Biol Ambientale, Rome, Italy;
9.Ist Italiano Antropol, Rome, Italy;
10.Univ Toulouse 3 Paul Sabatier, CNRS, Toulouse, France;
11.Univ Barcelona, Dept Anim Biol Anthropol, Biodivers Res Inst, Barcelona, Spain;
12.CNR, Ist Biol & Patol Mol, Rome, Italy
推荐引用方式
GB/T 7714
D’Atanasio, Eugenia,Trombetta, Beniamino,Bonito, Maria,et al. The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages[J],2018,19.
APA D’Atanasio, Eugenia.,Trombetta, Beniamino.,Bonito, Maria.,Finocchio, Andrea.,Di Vito, Genny.,...&Cruciani, Fulvio.(2018).The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages.GENOME BIOLOGY,19.
MLA D’Atanasio, Eugenia,et al."The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages".GENOME BIOLOGY 19(2018).
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