Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1002/etc.4242 |
Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients | |
Saari, Gavin N.1,2; Corrales, Jone1,2; Haddad, Samuel P.1,2; Chambliss, C. Kevin2,3; Brooks, Bryan W.1,2,4 | |
通讯作者 | Brooks, Bryan W. |
来源期刊 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
![]() |
ISSN | 0730-7268 |
EISSN | 1552-8618 |
出版年 | 2018 |
卷号 | 37期号:11页码:2835-2850 |
英文摘要 | Water resources in many arid to semi-arid regions are stressed by population growth and drought. Growing populations and climatic changes are influencing contaminant and water chemistry dynamics in urban inland waters, where flows can be dominated by, or even dependent on, wastewater effluent discharge. In these watersheds, interacting stressors such as dissolved oxygen and environmental contaminants (e.g., pharmaceuticals) have the potential to affect fish physiology and populations. Recent field observations from our group identified the calcium channel blocker (CCB) diltiazem in fish plasma exceeding human therapeutic doses (e.g., C-min) in aquatic systems impaired because of nonattainment of dissolved oxygen water quality standards. Therefore our study objectives examined: 1) standard acute and chronic effects of dissolved oxygen and diltiazem to fish, 2) influences of dissolved oxygen at criteria levels deemed protective of aquatic life on diltiazem toxicity to fish, and 3) whether sublethal effects occur at diltiazem water concentrations predicted to cause a human therapeutic level (therapeutic hazard value [THV]) in fish plasma. Dissolved oxygenxdiltiazem co-exposures significantly decreased survival at typical stream, lake, and reservoir water quality standards of 5.0 and 3.0mg dissolved oxygen/L. Dissolved oxygen and diltiazem growth effects were observed at 2 times and 10 times lower than median lethal concentration (LC50) values (1.7 and 28.2mg/L, respectively). Larval fathead minnow (Pimephales promelas) swimming behavior following low dissolved oxygen and diltiazem exposure generally decreased and was significantly reduced in light-to-dark bursting distance traveled, number of movements, and duration at concentrations as low as the THV. Individual and population level consequences of such responses are not yet understood, particularly in older organisms or other species; however, these findings suggest that assessments with pharmaceuticals and other cardioactive contaminants may underestimate adverse outcomes in fish across dissolved oxygen levels considered protective of aquatic life. Environ Toxicol Chem 2018;37:2835-2850. (c) 2018 SETAC |
英文关键词 | Dissolved oxygen Water quality criteria Pharmaceuticals Mixtures Contaminants of emerging concern Multiple Stressors |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000448832700007 |
WOS关键词 | THERAPEUTIC DRUG DILTIAZEM ; MEDAKA ORYZIAS-LATIPES ; PERSONAL CARE PRODUCTS ; READ-ACROSS HYPOTHESIS ; FRESH-WATER FISH ; HEMATOLOGICAL PARAMETERS ; PIMEPHALES-PROMELAS ; MOLECULAR RESPONSES ; PHYSIOLOGICAL-BASIS ; THERMAL TOLERANCE |
WOS类目 | Environmental Sciences ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/209167 |
作者单位 | 1.Baylor Univ, Dept Environm Sci, Waco, TX 76706 USA; 2.Baylor Univ, Ctr Reservoir & Aquat Syst Res, Waco, TX 76798 USA; 3.Baylor Univ, Dept Chem, Waco, TX 76798 USA; 4.Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA |
推荐引用方式 GB/T 7714 | Saari, Gavin N.,Corrales, Jone,Haddad, Samuel P.,et al. Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients[J],2018,37(11):2835-2850. |
APA | Saari, Gavin N.,Corrales, Jone,Haddad, Samuel P.,Chambliss, C. Kevin,&Brooks, Bryan W..(2018).Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,37(11),2835-2850. |
MLA | Saari, Gavin N.,et al."Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 37.11(2018):2835-2850. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。