Arid
DOI10.1002/ecs2.2427
An ecoimmunological approach to disease in tortoises reveals the importance of lymphocytes
Sandmeier, Franziska C.1; Weitzman, Chava L.2; Tracy, C. Richard2
通讯作者Sandmeier, Franziska C.
来源期刊ECOSPHERE
ISSN2150-8925
出版年2018
卷号9期号:9
英文摘要

We quantified the severity of upper respiratory tract disease (URTD) and immunological metrics (differential white blood cell counts and bacteria-killing ability of blood plasma) in relation to climatic variables in 20 populations of Mojave desert tortoise (Gopherus agassizii). Prevalence and infection intensity of Mycoplasma agassizii, an etiological agent of URTD, have previously been quantified for these populations (Weitzman et al. 2017). Immunological variables were reduced by principal component analyses and separated into cells involved in inflammation (PC1) and cellular functions mediated by lymphocytes and basophils (PC2). In population-level models, the mean number of lymphocytes per individual was associated with mean annual number of days below freezing. Lymphocytes were also positively associated with mean infection intensity of M. agassizii. Additionally, prevalence of URTD was closely associated with PC1 (cells associated with inflammation). This suggests that at least two immunological strategies are involved in responding to M.agassizii, one that involves primarily lymphocytes and one that involves inflammatory mechanisms. Recent studies on immunology in Testudines suggest that a large proportion of lymphocytes in this taxon are similar to B-1 lymphocytes of mammals and have phagocytic properties. Controlled experiments are needed to understand the disease mitigation of these lymphocytes in desert tortoises.


英文关键词chronic disease ectotherm inflammation phagocytosis reptile temperature
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000446834100031
WOS关键词RESPIRATORY-TRACT DISEASE ; MYCOPLASMA-AGASSIZII ; GOPHERUS-AGASSIZII ; B-CELLS ; DESERT ; ANTIBODIES ; PATTERNS
WOS类目Ecology
WOS研究方向Environmental Sciences & Ecology
来源机构Colorado State University
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/208850
作者单位1.Colorado State Univ Pueblo, Biol Dept, 2200 Bonforte Blvd, Pueblo, CO 81001 USA;
2.Univ Nevada, Dept Biol, Program Ecol Evolut & Conservat Biol, 1664 N Virginia St, Reno, NV 89557 USA
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Sandmeier, Franziska C.,Weitzman, Chava L.,Tracy, C. Richard. An ecoimmunological approach to disease in tortoises reveals the importance of lymphocytes[J]. Colorado State University,2018,9(9).
APA Sandmeier, Franziska C.,Weitzman, Chava L.,&Tracy, C. Richard.(2018).An ecoimmunological approach to disease in tortoises reveals the importance of lymphocytes.ECOSPHERE,9(9).
MLA Sandmeier, Franziska C.,et al."An ecoimmunological approach to disease in tortoises reveals the importance of lymphocytes".ECOSPHERE 9.9(2018).
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